Defects in Base Excision Repair Sensitize Cells to Manganese in S. cerevisiae

Manganese (Mn) is essential for normal physiologic functioning; therefore, deficiencies and excess intake of manganese can result in disease. In humans, prolonged exposure to manganese causes neurotoxicity characterized by Parkinson-like symptoms. Mn(2+) has been shown to mediate DNA damage possibly...

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Detalles Bibliográficos
Autores principales: Stephenson, Adrienne P., Mazu, Tryphon K., Miles, Jana S., Freeman, Miles D., Reams, R. Renee, Flores-Rozas, Hernan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825218/
https://www.ncbi.nlm.nih.gov/pubmed/24282812
http://dx.doi.org/10.1155/2013/295635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825218/
https://www.ncbi.nlm.nih.gov/pubmed/24282812
http://dx.doi.org/10.1155/2013/295635

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