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Transcriptional Control of Monocyte Gene Expression in Post-Traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) confers an increased risk for disorders with an inflammatory etiology. PTSD-related dysregulation of the sympathetic nervous system (SNS) and hypothalamic-pituitary adrenal (HPA) axis and associated alterations in inflammatory activity may contribute to this inc...

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Autores principales: O’Donovan, Aoife, Sun, Bing, Cole, Steve, Rempel, Hans, Lenoci, Maryann, Pulliam, Lynn, Neylan, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825251/
https://www.ncbi.nlm.nih.gov/pubmed/21508516
http://dx.doi.org/10.3233/DMA-2011-0768
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author O’Donovan, Aoife
Sun, Bing
Cole, Steve
Rempel, Hans
Lenoci, Maryann
Pulliam, Lynn
Neylan, Thomas
author_facet O’Donovan, Aoife
Sun, Bing
Cole, Steve
Rempel, Hans
Lenoci, Maryann
Pulliam, Lynn
Neylan, Thomas
author_sort O’Donovan, Aoife
collection PubMed
description Post-traumatic stress disorder (PTSD) confers an increased risk for disorders with an inflammatory etiology. PTSD-related dysregulation of the sympathetic nervous system (SNS) and hypothalamic-pituitary adrenal (HPA) axis and associated alterations in inflammatory activity may contribute to this increased risk. However, little is known about convergent SNS, HPA and inflammatory signaling at the level of the immune cell transcriptome in PTSD. To explore such signaling, we examined the prevalence of specific transcription factor binding motifs in the promoter regions of differentially expressed genes in monocytes from individuals with PTSD and matched controls. Participants included 49 men (24 PTSD+ and 25 trauma-exposed controls) and 18 women (10 PTSD+ and 8 controls). Men with PTSD showed up-regulation of target genes for the NF-κB/Rel family of transcription factors, which convey inflammatory signals, up-regulation of target genes for CREB/ATF transcription factors, which convey adrenergic signals from the SNS, and down-regulation of target genes for the glucocorticoid receptor, which conveys glucocorticoid signals from the HPA axis. Women with PTSD also showed significant up-regulation of target genes for NF-κB and non-significant down-regulation of target genes for GR, but significant down-regulation of target genes for CREB/ATF. Altered transcriptional control of monocyte gene expression could contribute to exaggerated inflammatory activity in PTSD.
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spelling pubmed-38252512013-12-01 Transcriptional Control of Monocyte Gene Expression in Post-Traumatic Stress Disorder O’Donovan, Aoife Sun, Bing Cole, Steve Rempel, Hans Lenoci, Maryann Pulliam, Lynn Neylan, Thomas Dis Markers Other Post-traumatic stress disorder (PTSD) confers an increased risk for disorders with an inflammatory etiology. PTSD-related dysregulation of the sympathetic nervous system (SNS) and hypothalamic-pituitary adrenal (HPA) axis and associated alterations in inflammatory activity may contribute to this increased risk. However, little is known about convergent SNS, HPA and inflammatory signaling at the level of the immune cell transcriptome in PTSD. To explore such signaling, we examined the prevalence of specific transcription factor binding motifs in the promoter regions of differentially expressed genes in monocytes from individuals with PTSD and matched controls. Participants included 49 men (24 PTSD+ and 25 trauma-exposed controls) and 18 women (10 PTSD+ and 8 controls). Men with PTSD showed up-regulation of target genes for the NF-κB/Rel family of transcription factors, which convey inflammatory signals, up-regulation of target genes for CREB/ATF transcription factors, which convey adrenergic signals from the SNS, and down-regulation of target genes for the glucocorticoid receptor, which conveys glucocorticoid signals from the HPA axis. Women with PTSD also showed significant up-regulation of target genes for NF-κB and non-significant down-regulation of target genes for GR, but significant down-regulation of target genes for CREB/ATF. Altered transcriptional control of monocyte gene expression could contribute to exaggerated inflammatory activity in PTSD. IOS Press 2011 2011-04-20 /pmc/articles/PMC3825251/ /pubmed/21508516 http://dx.doi.org/10.3233/DMA-2011-0768 Text en Copyright © 2011 Hindawi Publishing Corporation.
spellingShingle Other
O’Donovan, Aoife
Sun, Bing
Cole, Steve
Rempel, Hans
Lenoci, Maryann
Pulliam, Lynn
Neylan, Thomas
Transcriptional Control of Monocyte Gene Expression in Post-Traumatic Stress Disorder
title Transcriptional Control of Monocyte Gene Expression in Post-Traumatic Stress Disorder
title_full Transcriptional Control of Monocyte Gene Expression in Post-Traumatic Stress Disorder
title_fullStr Transcriptional Control of Monocyte Gene Expression in Post-Traumatic Stress Disorder
title_full_unstemmed Transcriptional Control of Monocyte Gene Expression in Post-Traumatic Stress Disorder
title_short Transcriptional Control of Monocyte Gene Expression in Post-Traumatic Stress Disorder
title_sort transcriptional control of monocyte gene expression in post-traumatic stress disorder
topic Other
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825251/
https://www.ncbi.nlm.nih.gov/pubmed/21508516
http://dx.doi.org/10.3233/DMA-2011-0768
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