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The use of supramolecular structures as protein ligands
Congo red dye as well as other eagerly self-assembling organic molecules which form rod-like or ribbon-like supramolecular structures in water solutions, appears to represent a new class of protein ligands with possible wide-ranging medical applications. Such molecules associate with proteins as int...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825278/ https://www.ncbi.nlm.nih.gov/pubmed/23296569 http://dx.doi.org/10.1007/s00894-012-1744-1 |
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author | Stopa, Barbara Jagusiak, Anna Konieczny, Leszek Piekarska, Barbara Rybarska, Janina Zemanek, Grzegorz Król, Marcin Piwowar, Piotr Roterman, Irena |
author_facet | Stopa, Barbara Jagusiak, Anna Konieczny, Leszek Piekarska, Barbara Rybarska, Janina Zemanek, Grzegorz Król, Marcin Piwowar, Piotr Roterman, Irena |
author_sort | Stopa, Barbara |
collection | PubMed |
description | Congo red dye as well as other eagerly self-assembling organic molecules which form rod-like or ribbon-like supramolecular structures in water solutions, appears to represent a new class of protein ligands with possible wide-ranging medical applications. Such molecules associate with proteins as integral clusters and preferentially penetrate into areas of low molecular stability. Abnormal, partly unfolded proteins are the main binding target for such ligands, while well packed molecules are generally inaccessible. Of particular interest is the observation that local susceptibility for binding supramolecular ligands may be promoted in some proteins as a consequence of function-derived structural changes, and that such complexation may alter the activity profile of target proteins. Examples are presented in this paper. |
format | Online Article Text |
id | pubmed-3825278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-38252782013-11-21 The use of supramolecular structures as protein ligands Stopa, Barbara Jagusiak, Anna Konieczny, Leszek Piekarska, Barbara Rybarska, Janina Zemanek, Grzegorz Król, Marcin Piwowar, Piotr Roterman, Irena J Mol Model Original Paper Congo red dye as well as other eagerly self-assembling organic molecules which form rod-like or ribbon-like supramolecular structures in water solutions, appears to represent a new class of protein ligands with possible wide-ranging medical applications. Such molecules associate with proteins as integral clusters and preferentially penetrate into areas of low molecular stability. Abnormal, partly unfolded proteins are the main binding target for such ligands, while well packed molecules are generally inaccessible. Of particular interest is the observation that local susceptibility for binding supramolecular ligands may be promoted in some proteins as a consequence of function-derived structural changes, and that such complexation may alter the activity profile of target proteins. Examples are presented in this paper. Springer Berlin Heidelberg 2013-01-08 2013 /pmc/articles/PMC3825278/ /pubmed/23296569 http://dx.doi.org/10.1007/s00894-012-1744-1 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Paper Stopa, Barbara Jagusiak, Anna Konieczny, Leszek Piekarska, Barbara Rybarska, Janina Zemanek, Grzegorz Król, Marcin Piwowar, Piotr Roterman, Irena The use of supramolecular structures as protein ligands |
title | The use of supramolecular structures as protein ligands |
title_full | The use of supramolecular structures as protein ligands |
title_fullStr | The use of supramolecular structures as protein ligands |
title_full_unstemmed | The use of supramolecular structures as protein ligands |
title_short | The use of supramolecular structures as protein ligands |
title_sort | use of supramolecular structures as protein ligands |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825278/ https://www.ncbi.nlm.nih.gov/pubmed/23296569 http://dx.doi.org/10.1007/s00894-012-1744-1 |
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