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The use of supramolecular structures as protein ligands

Congo red dye as well as other eagerly self-assembling organic molecules which form rod-like or ribbon-like supramolecular structures in water solutions, appears to represent a new class of protein ligands with possible wide-ranging medical applications. Such molecules associate with proteins as int...

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Autores principales: Stopa, Barbara, Jagusiak, Anna, Konieczny, Leszek, Piekarska, Barbara, Rybarska, Janina, Zemanek, Grzegorz, Król, Marcin, Piwowar, Piotr, Roterman, Irena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825278/
https://www.ncbi.nlm.nih.gov/pubmed/23296569
http://dx.doi.org/10.1007/s00894-012-1744-1
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author Stopa, Barbara
Jagusiak, Anna
Konieczny, Leszek
Piekarska, Barbara
Rybarska, Janina
Zemanek, Grzegorz
Król, Marcin
Piwowar, Piotr
Roterman, Irena
author_facet Stopa, Barbara
Jagusiak, Anna
Konieczny, Leszek
Piekarska, Barbara
Rybarska, Janina
Zemanek, Grzegorz
Król, Marcin
Piwowar, Piotr
Roterman, Irena
author_sort Stopa, Barbara
collection PubMed
description Congo red dye as well as other eagerly self-assembling organic molecules which form rod-like or ribbon-like supramolecular structures in water solutions, appears to represent a new class of protein ligands with possible wide-ranging medical applications. Such molecules associate with proteins as integral clusters and preferentially penetrate into areas of low molecular stability. Abnormal, partly unfolded proteins are the main binding target for such ligands, while well packed molecules are generally inaccessible. Of particular interest is the observation that local susceptibility for binding supramolecular ligands may be promoted in some proteins as a consequence of function-derived structural changes, and that such complexation may alter the activity profile of target proteins. Examples are presented in this paper.
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spelling pubmed-38252782013-11-21 The use of supramolecular structures as protein ligands Stopa, Barbara Jagusiak, Anna Konieczny, Leszek Piekarska, Barbara Rybarska, Janina Zemanek, Grzegorz Król, Marcin Piwowar, Piotr Roterman, Irena J Mol Model Original Paper Congo red dye as well as other eagerly self-assembling organic molecules which form rod-like or ribbon-like supramolecular structures in water solutions, appears to represent a new class of protein ligands with possible wide-ranging medical applications. Such molecules associate with proteins as integral clusters and preferentially penetrate into areas of low molecular stability. Abnormal, partly unfolded proteins are the main binding target for such ligands, while well packed molecules are generally inaccessible. Of particular interest is the observation that local susceptibility for binding supramolecular ligands may be promoted in some proteins as a consequence of function-derived structural changes, and that such complexation may alter the activity profile of target proteins. Examples are presented in this paper. Springer Berlin Heidelberg 2013-01-08 2013 /pmc/articles/PMC3825278/ /pubmed/23296569 http://dx.doi.org/10.1007/s00894-012-1744-1 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Paper
Stopa, Barbara
Jagusiak, Anna
Konieczny, Leszek
Piekarska, Barbara
Rybarska, Janina
Zemanek, Grzegorz
Król, Marcin
Piwowar, Piotr
Roterman, Irena
The use of supramolecular structures as protein ligands
title The use of supramolecular structures as protein ligands
title_full The use of supramolecular structures as protein ligands
title_fullStr The use of supramolecular structures as protein ligands
title_full_unstemmed The use of supramolecular structures as protein ligands
title_short The use of supramolecular structures as protein ligands
title_sort use of supramolecular structures as protein ligands
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825278/
https://www.ncbi.nlm.nih.gov/pubmed/23296569
http://dx.doi.org/10.1007/s00894-012-1744-1
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