Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers

The fibroblast growth factor receptors (FGFRs) regulate important biological processes including cell proliferation and differentiation during development and tissue repair. Over the past decades, numerous pathological conditions and developmental syndromes have emerged as a consequence of deregulat...

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Detalles Bibliográficos
Autores principales: Tiong, Kai Hung, Mah, Li Yen, Leong, Chee-Onn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825415/
https://www.ncbi.nlm.nih.gov/pubmed/23900974
http://dx.doi.org/10.1007/s10495-013-0886-7
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author Tiong, Kai Hung
Mah, Li Yen
Leong, Chee-Onn
author_facet Tiong, Kai Hung
Mah, Li Yen
Leong, Chee-Onn
author_sort Tiong, Kai Hung
collection PubMed
description The fibroblast growth factor receptors (FGFRs) regulate important biological processes including cell proliferation and differentiation during development and tissue repair. Over the past decades, numerous pathological conditions and developmental syndromes have emerged as a consequence of deregulation in the FGFRs signaling network. This review aims to provide an overview of FGFR family, their complex signaling pathways in tumorigenesis, and the current development and application of therapeutics targeting the FGFRs signaling for treatment of refractory human cancers.
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spelling pubmed-38254152013-11-21 Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers Tiong, Kai Hung Mah, Li Yen Leong, Chee-Onn Apoptosis Original Paper The fibroblast growth factor receptors (FGFRs) regulate important biological processes including cell proliferation and differentiation during development and tissue repair. Over the past decades, numerous pathological conditions and developmental syndromes have emerged as a consequence of deregulation in the FGFRs signaling network. This review aims to provide an overview of FGFR family, their complex signaling pathways in tumorigenesis, and the current development and application of therapeutics targeting the FGFRs signaling for treatment of refractory human cancers. Springer US 2013-07-31 2013 /pmc/articles/PMC3825415/ /pubmed/23900974 http://dx.doi.org/10.1007/s10495-013-0886-7 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Paper
Tiong, Kai Hung
Mah, Li Yen
Leong, Chee-Onn
Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers
title Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers
title_full Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers
title_fullStr Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers
title_full_unstemmed Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers
title_short Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers
title_sort functional roles of fibroblast growth factor receptors (fgfrs) signaling in human cancers
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825415/
https://www.ncbi.nlm.nih.gov/pubmed/23900974
http://dx.doi.org/10.1007/s10495-013-0886-7
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