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Estrogen, astrocytes and the neuroendocrine control of metabolism

Obesity, and its associated comorbidities such as type 2 diabetes, cardiovascular diseases, and certain cancers, represent major health challenges. Importantly, there is a sexual dimorphism with respect to the prevalence of obesity and its associated metabolic diseases, implicating a role for gonada...

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Autores principales: Fuente-Martin, E., Garcia-Caceres, C., Morselli, E., Clegg, D. J., Chowen, J. A., Finan, B., Brinton, R. D., Tschöp, M. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825572/
https://www.ncbi.nlm.nih.gov/pubmed/24009071
http://dx.doi.org/10.1007/s11154-013-9263-7
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author Fuente-Martin, E.
Garcia-Caceres, C.
Morselli, E.
Clegg, D. J.
Chowen, J. A.
Finan, B.
Brinton, R. D.
Tschöp, M. H.
author_facet Fuente-Martin, E.
Garcia-Caceres, C.
Morselli, E.
Clegg, D. J.
Chowen, J. A.
Finan, B.
Brinton, R. D.
Tschöp, M. H.
author_sort Fuente-Martin, E.
collection PubMed
description Obesity, and its associated comorbidities such as type 2 diabetes, cardiovascular diseases, and certain cancers, represent major health challenges. Importantly, there is a sexual dimorphism with respect to the prevalence of obesity and its associated metabolic diseases, implicating a role for gonadal hormones. Specifically, estrogens have been demonstrated to regulate metabolism perhaps by acting as a leptin mimetic in the central nervous system (CNS). CNS estrogen receptors (ERs) include ER alpha (ERα) and ER beta (ERβ), which are found in nuclear, cytoplasmic and membrane sites throughout the brain. Additionally, estrogens can bind to and activate a G protein-coupled estrogen receptor (GPER), which is a membrane-associated ER. ERs are expressed on neurons as well as glia, which are known to play a major role in providing nutrient supply for neurons and have recently received increasing attention for their potentially important involvement in the CNS regulation of systemic metabolism and energy balance. This brief overview summarizes data focusing on the potential role of astrocytic estrogen action as a key component of estrogenic modulation responsible for mediating the sexual dimorphism in body weight regulation and obesity.
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spelling pubmed-38255722013-11-21 Estrogen, astrocytes and the neuroendocrine control of metabolism Fuente-Martin, E. Garcia-Caceres, C. Morselli, E. Clegg, D. J. Chowen, J. A. Finan, B. Brinton, R. D. Tschöp, M. H. Rev Endocr Metab Disord Article Obesity, and its associated comorbidities such as type 2 diabetes, cardiovascular diseases, and certain cancers, represent major health challenges. Importantly, there is a sexual dimorphism with respect to the prevalence of obesity and its associated metabolic diseases, implicating a role for gonadal hormones. Specifically, estrogens have been demonstrated to regulate metabolism perhaps by acting as a leptin mimetic in the central nervous system (CNS). CNS estrogen receptors (ERs) include ER alpha (ERα) and ER beta (ERβ), which are found in nuclear, cytoplasmic and membrane sites throughout the brain. Additionally, estrogens can bind to and activate a G protein-coupled estrogen receptor (GPER), which is a membrane-associated ER. ERs are expressed on neurons as well as glia, which are known to play a major role in providing nutrient supply for neurons and have recently received increasing attention for their potentially important involvement in the CNS regulation of systemic metabolism and energy balance. This brief overview summarizes data focusing on the potential role of astrocytic estrogen action as a key component of estrogenic modulation responsible for mediating the sexual dimorphism in body weight regulation and obesity. Springer US 2013-09-06 2013 /pmc/articles/PMC3825572/ /pubmed/24009071 http://dx.doi.org/10.1007/s11154-013-9263-7 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Fuente-Martin, E.
Garcia-Caceres, C.
Morselli, E.
Clegg, D. J.
Chowen, J. A.
Finan, B.
Brinton, R. D.
Tschöp, M. H.
Estrogen, astrocytes and the neuroendocrine control of metabolism
title Estrogen, astrocytes and the neuroendocrine control of metabolism
title_full Estrogen, astrocytes and the neuroendocrine control of metabolism
title_fullStr Estrogen, astrocytes and the neuroendocrine control of metabolism
title_full_unstemmed Estrogen, astrocytes and the neuroendocrine control of metabolism
title_short Estrogen, astrocytes and the neuroendocrine control of metabolism
title_sort estrogen, astrocytes and the neuroendocrine control of metabolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825572/
https://www.ncbi.nlm.nih.gov/pubmed/24009071
http://dx.doi.org/10.1007/s11154-013-9263-7
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