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The role of the serotonergic system in suicidal behavior

Serotonin is a widely investigated neurotransmitter in several psychopathologies, including suicidal behavior (SB); however, its role extends to several physiological functions involving the nervous system, as well as the gastrointestinal and cardiovascular systems. This review summarizes recent res...

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Autores principales: Sadkowski, Marta, Dennis, Brittany, Clayden, Robert C, ElSheikh, Wala, Rangarajan, Sumathy, DeJesus, Jane, Samaan, Zainab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825712/
https://www.ncbi.nlm.nih.gov/pubmed/24235834
http://dx.doi.org/10.2147/NDT.S50300
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author Sadkowski, Marta
Dennis, Brittany
Clayden, Robert C
ElSheikh, Wala
Rangarajan, Sumathy
DeJesus, Jane
Samaan, Zainab
author_facet Sadkowski, Marta
Dennis, Brittany
Clayden, Robert C
ElSheikh, Wala
Rangarajan, Sumathy
DeJesus, Jane
Samaan, Zainab
author_sort Sadkowski, Marta
collection PubMed
description Serotonin is a widely investigated neurotransmitter in several psychopathologies, including suicidal behavior (SB); however, its role extends to several physiological functions involving the nervous system, as well as the gastrointestinal and cardiovascular systems. This review summarizes recent research into ten serotonergic genes related to SB. These genes – TPH1, TPH2, SLC6A4, SLC18A2, HTR1A, HTR1B, HTR2A, DDC, MAOA, and MAOB – encode proteins that are vital to serotonergic function: tryptophan hydroxylase; the serotonin transporter 5-HTT; the vesicular transporter VMAT2; the HTR(1A), HTR(1B), and HTR(2A) receptors; the L-amino acid decarboxylase; and the monoamine oxidases. This review employed a systematic search strategy and a narrative research methodology to disseminate the current literature investigating the link between SB and serotonin.
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spelling pubmed-38257122013-11-14 The role of the serotonergic system in suicidal behavior Sadkowski, Marta Dennis, Brittany Clayden, Robert C ElSheikh, Wala Rangarajan, Sumathy DeJesus, Jane Samaan, Zainab Neuropsychiatr Dis Treat Review Serotonin is a widely investigated neurotransmitter in several psychopathologies, including suicidal behavior (SB); however, its role extends to several physiological functions involving the nervous system, as well as the gastrointestinal and cardiovascular systems. This review summarizes recent research into ten serotonergic genes related to SB. These genes – TPH1, TPH2, SLC6A4, SLC18A2, HTR1A, HTR1B, HTR2A, DDC, MAOA, and MAOB – encode proteins that are vital to serotonergic function: tryptophan hydroxylase; the serotonin transporter 5-HTT; the vesicular transporter VMAT2; the HTR(1A), HTR(1B), and HTR(2A) receptors; the L-amino acid decarboxylase; and the monoamine oxidases. This review employed a systematic search strategy and a narrative research methodology to disseminate the current literature investigating the link between SB and serotonin. Dove Medical Press 2013 2013-11-06 /pmc/articles/PMC3825712/ /pubmed/24235834 http://dx.doi.org/10.2147/NDT.S50300 Text en © 2013 Sadkowski et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Sadkowski, Marta
Dennis, Brittany
Clayden, Robert C
ElSheikh, Wala
Rangarajan, Sumathy
DeJesus, Jane
Samaan, Zainab
The role of the serotonergic system in suicidal behavior
title The role of the serotonergic system in suicidal behavior
title_full The role of the serotonergic system in suicidal behavior
title_fullStr The role of the serotonergic system in suicidal behavior
title_full_unstemmed The role of the serotonergic system in suicidal behavior
title_short The role of the serotonergic system in suicidal behavior
title_sort role of the serotonergic system in suicidal behavior
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825712/
https://www.ncbi.nlm.nih.gov/pubmed/24235834
http://dx.doi.org/10.2147/NDT.S50300
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