Combining cellular and gene therapy approaches for treatment of intracranial tumors

New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were evaluated in xenograft models for human breast cancer. The individual and especially the combined treatments with alloreactive cytotoxic T lympho...

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Autores principales: Hickey, Michelle J, Kasahara, Noriyuki, Mueller, Barbara M, Kruse, Carol A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825732/
https://www.ncbi.nlm.nih.gov/pubmed/24244896
http://dx.doi.org/10.4161/onci.25989
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author Hickey, Michelle J
Kasahara, Noriyuki
Mueller, Barbara M
Kruse, Carol A
author_facet Hickey, Michelle J
Kasahara, Noriyuki
Mueller, Barbara M
Kruse, Carol A
author_sort Hickey, Michelle J
collection PubMed
description New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were evaluated in xenograft models for human breast cancer. The individual and especially the combined treatments with alloreactive cytotoxic T lymphocytes and replicating retroviral vectors coding for prodrug activating enzymes followed later with nontoxic prodrug demonstrated efficacy without off-target effects.
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spelling pubmed-38257322013-11-15 Combining cellular and gene therapy approaches for treatment of intracranial tumors Hickey, Michelle J Kasahara, Noriyuki Mueller, Barbara M Kruse, Carol A Oncoimmunology Author's View New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were evaluated in xenograft models for human breast cancer. The individual and especially the combined treatments with alloreactive cytotoxic T lymphocytes and replicating retroviral vectors coding for prodrug activating enzymes followed later with nontoxic prodrug demonstrated efficacy without off-target effects. Landes Bioscience 2013-10-01 2013-09-12 /pmc/articles/PMC3825732/ /pubmed/24244896 http://dx.doi.org/10.4161/onci.25989 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Hickey, Michelle J
Kasahara, Noriyuki
Mueller, Barbara M
Kruse, Carol A
Combining cellular and gene therapy approaches for treatment of intracranial tumors
title Combining cellular and gene therapy approaches for treatment of intracranial tumors
title_full Combining cellular and gene therapy approaches for treatment of intracranial tumors
title_fullStr Combining cellular and gene therapy approaches for treatment of intracranial tumors
title_full_unstemmed Combining cellular and gene therapy approaches for treatment of intracranial tumors
title_short Combining cellular and gene therapy approaches for treatment of intracranial tumors
title_sort combining cellular and gene therapy approaches for treatment of intracranial tumors
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825732/
https://www.ncbi.nlm.nih.gov/pubmed/24244896
http://dx.doi.org/10.4161/onci.25989
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