Cargando…

Invasive micropapillary carcinoma of the breast in a male patient: Report of a case()

INTRODUCTION: We report a rare case of invasive micropapillary carcinoma in the male breast. PRESENTATION OF CASE: A 63-year-old man was referred to our hospital for investigation of a left breast tumor, which could be palpated in the upper lateral quadrant of the left nipple-areola complex. The tum...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsushimi, Takaaki, Mori, Hirohito, Harada, Takasuke, Ikeda, Yoshitaka, Ohnishi, Hiromi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825973/
https://www.ncbi.nlm.nih.gov/pubmed/24076565
http://dx.doi.org/10.1016/j.ijscr.2013.09.001
_version_ 1782290857665232896
author Tsushimi, Takaaki
Mori, Hirohito
Harada, Takasuke
Ikeda, Yoshitaka
Ohnishi, Hiromi
author_facet Tsushimi, Takaaki
Mori, Hirohito
Harada, Takasuke
Ikeda, Yoshitaka
Ohnishi, Hiromi
author_sort Tsushimi, Takaaki
collection PubMed
description INTRODUCTION: We report a rare case of invasive micropapillary carcinoma in the male breast. PRESENTATION OF CASE: A 63-year-old man was referred to our hospital for investigation of a left breast tumor, which could be palpated in the upper lateral quadrant of the left nipple-areola complex. The tumor invaded the areola skin. Ultrasonography showed a 14.8 × 15.0 × 12.4 mm low echoic mass, with an irregular lobulated border. Core needle biopsy indicated invasive ductal carcinoma, but the subtype could not be accurately determined. Mastectomy with axillary lymph node dissection was performed. Pathological examination indicated invasive micropapillary carcinoma, no lymph node metastasis, and a nuclear grade of 2. Immunohistochemical examination showed positive staining for estrogen and progesterone receptors, but negative staining for HER2. The Ki67 index was 5%. Tamoxifen was administered, and recurrence has not been noted for 1 year. DISCUSSION: Women's IMPC generally shows a high HER2 positivity rate. However, HER2 positivity was noted in only 1 male patient with IMPC (14%) according to our literature review. Furthermore, in all cases of the mixed type that were reviewed, IMPC was associated with papillotubular carcinoma. These findings may be specific to IMPC in male patients. CONCLUSION: IMPC is associated with a high rate of lymph node metastasis or recurrence and advanced vessel invasion, aggressive adjuvant chemotherapy following surgical resection should be selected for patients with IMPC.
format Online
Article
Text
id pubmed-3825973
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-38259732013-11-13 Invasive micropapillary carcinoma of the breast in a male patient: Report of a case() Tsushimi, Takaaki Mori, Hirohito Harada, Takasuke Ikeda, Yoshitaka Ohnishi, Hiromi Int J Surg Case Rep Article INTRODUCTION: We report a rare case of invasive micropapillary carcinoma in the male breast. PRESENTATION OF CASE: A 63-year-old man was referred to our hospital for investigation of a left breast tumor, which could be palpated in the upper lateral quadrant of the left nipple-areola complex. The tumor invaded the areola skin. Ultrasonography showed a 14.8 × 15.0 × 12.4 mm low echoic mass, with an irregular lobulated border. Core needle biopsy indicated invasive ductal carcinoma, but the subtype could not be accurately determined. Mastectomy with axillary lymph node dissection was performed. Pathological examination indicated invasive micropapillary carcinoma, no lymph node metastasis, and a nuclear grade of 2. Immunohistochemical examination showed positive staining for estrogen and progesterone receptors, but negative staining for HER2. The Ki67 index was 5%. Tamoxifen was administered, and recurrence has not been noted for 1 year. DISCUSSION: Women's IMPC generally shows a high HER2 positivity rate. However, HER2 positivity was noted in only 1 male patient with IMPC (14%) according to our literature review. Furthermore, in all cases of the mixed type that were reviewed, IMPC was associated with papillotubular carcinoma. These findings may be specific to IMPC in male patients. CONCLUSION: IMPC is associated with a high rate of lymph node metastasis or recurrence and advanced vessel invasion, aggressive adjuvant chemotherapy following surgical resection should be selected for patients with IMPC. Elsevier 2013-09-09 /pmc/articles/PMC3825973/ /pubmed/24076565 http://dx.doi.org/10.1016/j.ijscr.2013.09.001 Text en © 2013 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Tsushimi, Takaaki
Mori, Hirohito
Harada, Takasuke
Ikeda, Yoshitaka
Ohnishi, Hiromi
Invasive micropapillary carcinoma of the breast in a male patient: Report of a case()
title Invasive micropapillary carcinoma of the breast in a male patient: Report of a case()
title_full Invasive micropapillary carcinoma of the breast in a male patient: Report of a case()
title_fullStr Invasive micropapillary carcinoma of the breast in a male patient: Report of a case()
title_full_unstemmed Invasive micropapillary carcinoma of the breast in a male patient: Report of a case()
title_short Invasive micropapillary carcinoma of the breast in a male patient: Report of a case()
title_sort invasive micropapillary carcinoma of the breast in a male patient: report of a case()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825973/
https://www.ncbi.nlm.nih.gov/pubmed/24076565
http://dx.doi.org/10.1016/j.ijscr.2013.09.001
work_keys_str_mv AT tsushimitakaaki invasivemicropapillarycarcinomaofthebreastinamalepatientreportofacase
AT morihirohito invasivemicropapillarycarcinomaofthebreastinamalepatientreportofacase
AT haradatakasuke invasivemicropapillarycarcinomaofthebreastinamalepatientreportofacase
AT ikedayoshitaka invasivemicropapillarycarcinomaofthebreastinamalepatientreportofacase
AT ohnishihiromi invasivemicropapillarycarcinomaofthebreastinamalepatientreportofacase