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A rare case of ethambutol induced pulmonary eosinophilia
Antitubercular drug (ATD) induced eosinophilic lung disease is a rare phenomenon. It usually occurs due to isoniazid and para amino salicylic acid. A 34-year-male of sputum positive pulmonary tuberculosis, on antitubercular drugs (rifampicin, isoniazid, ethambutol, and pyrazinamide) for last 3 weeks...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826012/ https://www.ncbi.nlm.nih.gov/pubmed/24250213 http://dx.doi.org/10.4103/0976-500X.119724 |
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author | Saha, Kaushik Bandyopadhyay, Ankan Sengupta, Amitabha Jash, Debraj |
author_facet | Saha, Kaushik Bandyopadhyay, Ankan Sengupta, Amitabha Jash, Debraj |
author_sort | Saha, Kaushik |
collection | PubMed |
description | Antitubercular drug (ATD) induced eosinophilic lung disease is a rare phenomenon. It usually occurs due to isoniazid and para amino salicylic acid. A 34-year-male of sputum positive pulmonary tuberculosis, on antitubercular drugs (rifampicin, isoniazid, ethambutol, and pyrazinamide) for last 3 weeks, presented with generalized arthralgia and maculopapular rash for last 2 weeks and shortness of breath for last 1 week. Chest X-ray and High resolution computerized tomographic scan thorax showed bilateral peripheral airspace opacification. Bronchoalveolar lavage revealed 51% eosinophils of total cellularity (1200/cmm) confirming the diagnosis of pulmonary eosinophilia. ATD was stopped for 2 weeks and then reintroduced one by one. Patient again developed similar kind of symptoms with reintroduction of ethambutol. According to criteria for drug induced pulmonary eosinophilia, he was diagnosed as a case of ethambutol induced pulmonary eosinophilia. |
format | Online Article Text |
id | pubmed-3826012 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38260122013-11-18 A rare case of ethambutol induced pulmonary eosinophilia Saha, Kaushik Bandyopadhyay, Ankan Sengupta, Amitabha Jash, Debraj J Pharmacol Pharmacother Case Report Antitubercular drug (ATD) induced eosinophilic lung disease is a rare phenomenon. It usually occurs due to isoniazid and para amino salicylic acid. A 34-year-male of sputum positive pulmonary tuberculosis, on antitubercular drugs (rifampicin, isoniazid, ethambutol, and pyrazinamide) for last 3 weeks, presented with generalized arthralgia and maculopapular rash for last 2 weeks and shortness of breath for last 1 week. Chest X-ray and High resolution computerized tomographic scan thorax showed bilateral peripheral airspace opacification. Bronchoalveolar lavage revealed 51% eosinophils of total cellularity (1200/cmm) confirming the diagnosis of pulmonary eosinophilia. ATD was stopped for 2 weeks and then reintroduced one by one. Patient again developed similar kind of symptoms with reintroduction of ethambutol. According to criteria for drug induced pulmonary eosinophilia, he was diagnosed as a case of ethambutol induced pulmonary eosinophilia. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3826012/ /pubmed/24250213 http://dx.doi.org/10.4103/0976-500X.119724 Text en Copyright: © Journal of Pharmacology and Pharmacotherapeutics http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Saha, Kaushik Bandyopadhyay, Ankan Sengupta, Amitabha Jash, Debraj A rare case of ethambutol induced pulmonary eosinophilia |
title | A rare case of ethambutol induced pulmonary eosinophilia |
title_full | A rare case of ethambutol induced pulmonary eosinophilia |
title_fullStr | A rare case of ethambutol induced pulmonary eosinophilia |
title_full_unstemmed | A rare case of ethambutol induced pulmonary eosinophilia |
title_short | A rare case of ethambutol induced pulmonary eosinophilia |
title_sort | rare case of ethambutol induced pulmonary eosinophilia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826012/ https://www.ncbi.nlm.nih.gov/pubmed/24250213 http://dx.doi.org/10.4103/0976-500X.119724 |
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