PTPN2 is Associated with Crohn’s Disease and Its Expression Is Regulated by NKX2-3

PTPN2 is a risk gene for Crohn's disease (CD). We investigated whether PTPN2 genetic variants (rs2542151 and rs2542152) were associated with CD in a familial IBD registry. Both rs2542151 and rs2542152 are associated with CD, but not ulcerative colitis (UC). mRNA expression levels of PTPN2 were...

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Detalles Bibliográficos
Autores principales: Yu, Wei, Hegarty, John P., Berg, Arthur, Kelly, Ashley A., Wang, Yunhua, Poritz, Lisa S., Franke, Andre, Schreiber, Stefan, Koltun, Walter A., Lin, Zhenwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2012
Materias:
Other
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826479/
https://www.ncbi.nlm.nih.gov/pubmed/22377701
http://dx.doi.org/10.3233/DMA-2011-0867

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