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Akt-p53-miR-365-cyclin D1/cdc25A axis contributes to gastric tumorigenesis induced by PTEN deficiency

Although PTEN/Akt signaling is frequently deregulated in human gastric cancers, the in vivo causal link between its dysregulation and gastric tumorigenesis has not been established. Here we show that inactivation of PTEN in mouse gastric epithelium initiates spontaneous carcinogenesis with complete...

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Detalles Bibliográficos
Autores principales:	Guo, Shui-Long, Ye, Hui, Teng, Yan, Wang, You-Liang, Yang, Guan, Li, Xiu-Bin, Zhang, Chong, Yang, Xue, Yang, Zhong-Zhou, Yang, Xiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826643/ https://www.ncbi.nlm.nih.gov/pubmed/24149576 http://dx.doi.org/10.1038/ncomms3544

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