Horizontal gene transfer converts non-toxigenic Clostridium difficile strains into toxin producers

Clostridium difficile is a major nosocomial pathogen and the main causative agent of antibiotic-associated diarrhoea. The organism produces two potent toxins, A and B, which are its major virulence factors. These are chromosomally encoded on a region termed the pathogenicity locus (PaLoc), which als...

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Detalles Bibliográficos
Autores principales: Brouwer, Michael S.M., Roberts, Adam P., Hussain, Haitham, Williams, Rachel J., Allan, Elaine, Mullany, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826655/
https://www.ncbi.nlm.nih.gov/pubmed/24131955
http://dx.doi.org/10.1038/ncomms3601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826655/
https://www.ncbi.nlm.nih.gov/pubmed/24131955
http://dx.doi.org/10.1038/ncomms3601

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