HIV-1 infection, response to treatment and establishment of viral latency in a novel humanized T cell-only mouse (TOM) model

BACKGROUND: The major targets of HIV infection in humans are CD4(+) T cells. CD4(+) T cell depletion is a hallmark of AIDS. Previously, the SCID-hu thy/liv model was used to study the effect of HIV on thymopoeisis in vivo. However, these mice did not develop high levels of peripheral T cell reconsti...

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Detalles Bibliográficos
Autores principales: Honeycutt, Jenna B, Wahl, Angela, Archin, Nancie, Choudhary, Shailesh, Margolis, David, Garcia, J Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826870/
https://www.ncbi.nlm.nih.gov/pubmed/24156277
http://dx.doi.org/10.1186/1742-4690-10-121

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