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Facilitation of Relational Learning in Schizophrenia
Abnormal hippocampal function likely contributes to relational learning deficits observed in schizophrenia. It is unknown whether these deficits can be attenuated with a training intervention. The purpose of this project was to determine if training could facilitate relational learning of the transv...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826982/ https://www.ncbi.nlm.nih.gov/pubmed/24244873 http://dx.doi.org/10.3390/bs3020206 |
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author | Spieker, Elena A. Griego, Jacqueline A. Astur, Robert S. Holcomb, Henry H. Rowland, Laura M. |
author_facet | Spieker, Elena A. Griego, Jacqueline A. Astur, Robert S. Holcomb, Henry H. Rowland, Laura M. |
author_sort | Spieker, Elena A. |
collection | PubMed |
description | Abnormal hippocampal function likely contributes to relational learning deficits observed in schizophrenia. It is unknown whether these deficits can be attenuated with a training intervention. The purpose of this project was to determine if training could facilitate relational learning of the transverse patterning task in schizophrenia. Healthy and schizophrenia subjects completed a version of transverse patterning that incorporated training. The majority of subjects with schizophrenia successfully learned transverse patterning when provided with training. A subgroup (approximately 25%) of schizophrenia subjects showed no tendency to learn with training. These results were replicated in a second study with a separate cohort and different stimuli. This study illustrates that relational learning of the transverse patterning can be facilitated in schizophrenia with training. |
format | Online Article Text |
id | pubmed-3826982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-38269822013-11-13 Facilitation of Relational Learning in Schizophrenia Spieker, Elena A. Griego, Jacqueline A. Astur, Robert S. Holcomb, Henry H. Rowland, Laura M. Behav Sci (Basel) Article Abnormal hippocampal function likely contributes to relational learning deficits observed in schizophrenia. It is unknown whether these deficits can be attenuated with a training intervention. The purpose of this project was to determine if training could facilitate relational learning of the transverse patterning task in schizophrenia. Healthy and schizophrenia subjects completed a version of transverse patterning that incorporated training. The majority of subjects with schizophrenia successfully learned transverse patterning when provided with training. A subgroup (approximately 25%) of schizophrenia subjects showed no tendency to learn with training. These results were replicated in a second study with a separate cohort and different stimuli. This study illustrates that relational learning of the transverse patterning can be facilitated in schizophrenia with training. MDPI 2013-04-12 /pmc/articles/PMC3826982/ /pubmed/24244873 http://dx.doi.org/10.3390/bs3020206 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Spieker, Elena A. Griego, Jacqueline A. Astur, Robert S. Holcomb, Henry H. Rowland, Laura M. Facilitation of Relational Learning in Schizophrenia |
title | Facilitation of Relational Learning in Schizophrenia |
title_full | Facilitation of Relational Learning in Schizophrenia |
title_fullStr | Facilitation of Relational Learning in Schizophrenia |
title_full_unstemmed | Facilitation of Relational Learning in Schizophrenia |
title_short | Facilitation of Relational Learning in Schizophrenia |
title_sort | facilitation of relational learning in schizophrenia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826982/ https://www.ncbi.nlm.nih.gov/pubmed/24244873 http://dx.doi.org/10.3390/bs3020206 |
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