Cargando…

A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates

Endoplasmic reticulum (ER) membrane–bound E3 ubiquitin ligases promote ER-associated degradation (ERAD) by ubiquitinating a retro-translocated substrate that reaches the cytosol from the ER, targeting it to the proteasome for destruction. Recent findings implicate ERAD-associated deubiquitinases (DU...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bernardi, Kaleena M., Williams, Jeffrey M., Inoue, Takamasa, Schultz, Aric, Tsai, Billy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826992/ https://www.ncbi.nlm.nih.gov/pubmed/24068323 http://dx.doi.org/10.1091/mbc.E13-06-0332

Ejemplares similares

The Ero1α-PDI Redox Cycle Regulates Retro-Translocation of Cholera Toxin
por: Moore, Paul, et al.
Publicado: (2010)

The E3 Ubiquitin Ligases Hrd1 and gp78 Bind to and Promote Cholera Toxin Retro-Translocation
por: Bernardi, Kaleena M., et al.
Publicado: (2010)

Establishment of an In Vitro Transport Assay That Reveals Mechanistic Differences in Cytosolic Events Controlling Cholera Toxin and T-Cell Receptor α Retro-Translocation
por: Moore, Paul, et al.
Publicado: (2013)

A Non-enveloped Virus Hijacks Host Disaggregation Machinery to Translocate across the Endoplasmic Reticulum Membrane
por: Ravindran, Madhu Sudhan, et al.
Publicado: (2015)

Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins
por: Cho, Jin A., et al.
Publicado: (2012)

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
por: Damgaard, Rune Busk, et al.
Publicado: (2016)

Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection
por: Shin, Donghyuk, et al.
Publicado: (2020)

Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains
por: Ye, Yihong, et al.
Publicado: (2003)

The ERdj5-Sel1L complex facilitates cholera toxin retrotranslocation
por: Williams, Jeffrey M., et al.
Publicado: (2013)

The nucleotide exchange factors Grp170 and Sil1 induce cholera toxin release from BiP to enable retrotranslocation
por: Williams, Jeffrey M., et al.
Publicado: (2015)

Regulated Erlin-dependent release of the B12 transmembrane J-protein promotes ER membrane penetration of a non-enveloped virus
por: Inoue, Takamasa, et al.
Publicado: (2017)

Efficient Detection of Proteins Retro-Translocated from the ER to the Cytosol by In Vivo Biotinylation
por: Petris, Gianluca, et al.
Publicado: (2011)

SVIP regulates Z variant alpha-1 antitrypsin retro-translocation by inhibiting ubiquitin ligase gp78
por: Khodayari, Nazli, et al.
Publicado: (2017)

Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome
por: Bashore, Charlene, et al.
Publicado: (2015)

A Large and Intact Viral Particle Penetrates the Endoplasmic Reticulum Membrane to Reach the Cytosol
por: Inoue, Takamasa, et al.
Publicado: (2011)

The Grp170 nucleotide exchange factor executes a key role during ERAD of cellular misfolded clients
por: Inoue, Takamasa, et al.
Publicado: (2016)

USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase
por: Fan, Yihui, et al.
Publicado: (2014)

The deubiquitinase UCHL1 negatively controls osteoclastogenesis by regulating TAZ/NFATC1 signalling
por: Feng, Zhenhua, et al.
Publicado: (2023)

Deubiquitinases as pivotal regulators of T cell functions
por: Yang, Xiao-Dong, et al.
Publicado: (2018)

Molecular Regulation of the Polycomb Repressive-Deubiquitinase
por: Reddington, Cameron J., et al.
Publicado: (2020)

Deubiquitinases Sharpen Substrate Discrimination during Membrane Protein Degradation from the ER
por: Zhang, Zai-Rong, et al.
Publicado: (2013)

Native Semisynthesis of Isopeptide-Linked Substrates for Specificity Analysis of Deubiquitinases and Ubl Proteases
por: Zhao, Zhou, et al.
Publicado: (2023)

Deubiquitinases in cancer
por: Wei, Rongbin, et al.
Publicado: (2015)

Deubiquitinases in Neurodegeneration
por: Bello, Abudu I., et al.
Publicado: (2022)

Modern retro /
por: Bingham, Neil R.
Publicado: (2000)

Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and Product
por: Shrestha, Rashmi K., et al.
Publicado: (2014)

Elevation of Proteasomal Substrate Levels Sensitizes Cells to Apoptosis Induced by Inhibition of Proteasomal Deubiquitinases
por: Sun, Chao, et al.
Publicado: (2014)

Retro-retinoids in regulated cell growth and death
Publicado: (1996)

EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus
por: Bagchi, Parikshit, et al.
Publicado: (2016)

Tandem UIMs confer Lys48 ubiquitin chain substrate preference to deubiquitinase USP25
por: Kawaguchi, Kohei, et al.
Publicado: (2017)

Deep-learning based approach to identify substrates of human E3 ubiquitin ligases and deubiquitinases
por: Shu, Yixuan, et al.
Publicado: (2023)

Deubiquitinases in hematological malignancies
por: Lei, Hu, et al.
Publicado: (2021)

Retro-Ocular Neuritis
por: Shorten, J. H.
Publicado: (1910)

Papillomaviruses Go Retro
por: Xie, Jian, et al.
Publicado: (2020)

On Hæmatocele Retro-Uterina
por: Ferber, Rud.
Publicado: (1864)

The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism
por: Ruiz-Serrano, Amalia, et al.
Publicado: (2022)

Deubiquitinases: Modulators of Different Types of Regulated Cell Death
por: Lee, Choong-Sil, et al.
Publicado: (2021)

The Regulation and Double-Edged Roles of the Deubiquitinase OTUD5
por: Fu, Lin, et al.
Publicado: (2023)

CYLD Deubiquitinase Negatively Regulates High Glucose-Induced NF-κB Inflammatory Signaling in Mesangial Cells
por: Li, Yanhui, et al.
Publicado: (2017)

A Retro-Perspective on Auxin Transport
por: Geisler, Markus M.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_n4dofnmkcd4vvqthliqrfblfqi