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Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination
Alkylating chemotherapy exerts both antineoplastic and immunostimulatory effects. However, in addition to depleting regulatory T cells (Treg), alkylating agents also mediate a long lasting antiproliferative effect on responder lymphocytes. Our recent findings indicate that this antiproliferative eff...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827073/ https://www.ncbi.nlm.nih.gov/pubmed/24251080 http://dx.doi.org/10.4161/onci.26294 |
| _version_ | 1782290999771398144 |
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| author | Litterman, Adam J Dudek, Arkadiusz Z Largaespada, David A |
| author_facet | Litterman, Adam J Dudek, Arkadiusz Z Largaespada, David A |
| author_sort | Litterman, Adam J |
| collection | PubMed |
| description | Alkylating chemotherapy exerts both antineoplastic and immunostimulatory effects. However, in addition to depleting regulatory T cells (Treg), alkylating agents also mediate a long lasting antiproliferative effect on responder lymphocytes. Our recent findings indicate that this antiproliferative effect profoundly impairs vaccination-induced immune responses, especially in the case of vaccines that target specific tumor-associated neo-antigens that do not require Treg depletion. |
| format | Online Article Text |
| id | pubmed-3827073 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-38270732013-11-18 Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination Litterman, Adam J Dudek, Arkadiusz Z Largaespada, David A Oncoimmunology Point of View Alkylating chemotherapy exerts both antineoplastic and immunostimulatory effects. However, in addition to depleting regulatory T cells (Treg), alkylating agents also mediate a long lasting antiproliferative effect on responder lymphocytes. Our recent findings indicate that this antiproliferative effect profoundly impairs vaccination-induced immune responses, especially in the case of vaccines that target specific tumor-associated neo-antigens that do not require Treg depletion. Landes Bioscience 2013-10-01 2013-10-15 /pmc/articles/PMC3827073/ /pubmed/24251080 http://dx.doi.org/10.4161/onci.26294 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Point of View Litterman, Adam J Dudek, Arkadiusz Z Largaespada, David A Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination |
| title | Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination |
| title_full | Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination |
| title_fullStr | Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination |
| title_full_unstemmed | Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination |
| title_short | Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination |
| title_sort | alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination |
| topic | Point of View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827073/ https://www.ncbi.nlm.nih.gov/pubmed/24251080 http://dx.doi.org/10.4161/onci.26294 |
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