Systemic Administration of Substance P Recovers Beta Amyloid-Induced Cognitive Deficits in Rat: Involvement of Kv Potassium Channels

Reduced levels of Substance P (SP), an endogenous neuropeptide endowed with neuroprotective and anti-apoptotic properties, have been found in brain and spinal fluid of Alzheimer's disease (AD) patients. Potassium (K(+)) channel dysfunction is implicated in AD development and the amyloid-β (Aβ)-...

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Detalles Bibliográficos
Autores principales: Campolongo, Patrizia, Ratano, Patrizia, Ciotti, Maria Teresa, Florenzano, Fulvio, Nori, Stefania Lucia, Marolda, Roberta, Palmery, Maura, Rinaldi, Anna Maria, Zona, Cristina, Possenti, Roberta, Calissano, Pietro, Severini, Cinzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827079/
https://www.ncbi.nlm.nih.gov/pubmed/24265678
http://dx.doi.org/10.1371/journal.pone.0078036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827079/
https://www.ncbi.nlm.nih.gov/pubmed/24265678
http://dx.doi.org/10.1371/journal.pone.0078036

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