Crystal Structures of Trypanosoma brucei Oligopeptidase B Broaden the Paradigm of Catalytic Regulation in Prolyl Oligopeptidase Family Enzymes

Oligopeptidase B cleaves after basic amino acids in peptides up to 30 residues. As a virulence factor in bacteria and trypanosomatid pathogens that is absent in higher eukaryotes, this is a promising drug target. Here we present ligand-free open state and inhibitor-bound closed state crystal structu...

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Detalles Bibliográficos
Autores principales: Canning, Peter, Rea, Dean, Morty, Rory E., Fülöp, Vilmos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827171/
https://www.ncbi.nlm.nih.gov/pubmed/24265767
http://dx.doi.org/10.1371/journal.pone.0079349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827171/
https://www.ncbi.nlm.nih.gov/pubmed/24265767
http://dx.doi.org/10.1371/journal.pone.0079349

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