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Monocyte Chemotactic Protein-1 (MCP-1) in Patients with Chronic Schistosomiasis Mansoni: Evidences of Subclinical Renal Inflammation

The aim of this study is to investigate renal markers and the biomarker MCP-1 in patients with schistosomiasis mansoni. This is a cross-sectional study with 85 patients aged 5 to 48 years, with a confirmed diagnosis of schistosomiasis mansoni through the Kato-Katz method. The patients were divided i...

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Autores principales: Hanemann, Ana Lúcia P., Libório, Alexandre B., Daher, Elizabeth F., Martins, Alice Maria C., Pinheiro, Marta Cristhiany C., Sousa, Mariana S., Bezerra, Fernando Schemelzer M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827226/
https://www.ncbi.nlm.nih.gov/pubmed/24265821
http://dx.doi.org/10.1371/journal.pone.0080421
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author Hanemann, Ana Lúcia P.
Libório, Alexandre B.
Daher, Elizabeth F.
Martins, Alice Maria C.
Pinheiro, Marta Cristhiany C.
Sousa, Mariana S.
Bezerra, Fernando Schemelzer M.
author_facet Hanemann, Ana Lúcia P.
Libório, Alexandre B.
Daher, Elizabeth F.
Martins, Alice Maria C.
Pinheiro, Marta Cristhiany C.
Sousa, Mariana S.
Bezerra, Fernando Schemelzer M.
author_sort Hanemann, Ana Lúcia P.
collection PubMed
description The aim of this study is to investigate renal markers and the biomarker MCP-1 in patients with schistosomiasis mansoni. This is a cross-sectional study with 85 patients aged 5 to 48 years, with a confirmed diagnosis of schistosomiasis mansoni through the Kato-Katz method. The patients were divided in three groups: control (G-I); infected by S. mansoni before treatment (G-II) and infected by S. mansoni after treatment (G-III). Renal function was evaluated by tubular and glomerular biomarkers and through urinary MCP-1. Patients’ mean age was 23.2±13 years. There was no statistically significant difference between the groups regarding tubular and glomerular function evaluated through the traditional biomarkers. MCP-1 was higher in G-II and G-III, when compared to G-I; p=0.009 and p=0.007, respectively. There was no difference when comparing groups G-II and G-III (p=0.892). Although it was not different among the groups, there was a significant correlation between albuminuria and MCP-1. There was a significant increase in urinary MCP-1 levels in patients with schistosomiasis mansoni, which was associated with albuminuria. This protein has a role in the recruitment of monocytes to injury and inflammation sites . The increase of MCP-1 in the urine evidences that there is silent renal inflammation in these patients and the inflammatory status is not interrupted by specific treatment of the offending agent. Our findings suggest that urinary MCP-1 can be a sensitive marker of renal injury in patients with schistosomiasis mansoni.
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spelling pubmed-38272262013-11-21 Monocyte Chemotactic Protein-1 (MCP-1) in Patients with Chronic Schistosomiasis Mansoni: Evidences of Subclinical Renal Inflammation Hanemann, Ana Lúcia P. Libório, Alexandre B. Daher, Elizabeth F. Martins, Alice Maria C. Pinheiro, Marta Cristhiany C. Sousa, Mariana S. Bezerra, Fernando Schemelzer M. PLoS One Research Article The aim of this study is to investigate renal markers and the biomarker MCP-1 in patients with schistosomiasis mansoni. This is a cross-sectional study with 85 patients aged 5 to 48 years, with a confirmed diagnosis of schistosomiasis mansoni through the Kato-Katz method. The patients were divided in three groups: control (G-I); infected by S. mansoni before treatment (G-II) and infected by S. mansoni after treatment (G-III). Renal function was evaluated by tubular and glomerular biomarkers and through urinary MCP-1. Patients’ mean age was 23.2±13 years. There was no statistically significant difference between the groups regarding tubular and glomerular function evaluated through the traditional biomarkers. MCP-1 was higher in G-II and G-III, when compared to G-I; p=0.009 and p=0.007, respectively. There was no difference when comparing groups G-II and G-III (p=0.892). Although it was not different among the groups, there was a significant correlation between albuminuria and MCP-1. There was a significant increase in urinary MCP-1 levels in patients with schistosomiasis mansoni, which was associated with albuminuria. This protein has a role in the recruitment of monocytes to injury and inflammation sites . The increase of MCP-1 in the urine evidences that there is silent renal inflammation in these patients and the inflammatory status is not interrupted by specific treatment of the offending agent. Our findings suggest that urinary MCP-1 can be a sensitive marker of renal injury in patients with schistosomiasis mansoni. Public Library of Science 2013-11-12 /pmc/articles/PMC3827226/ /pubmed/24265821 http://dx.doi.org/10.1371/journal.pone.0080421 Text en © 2013 Hanemann et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hanemann, Ana Lúcia P.
Libório, Alexandre B.
Daher, Elizabeth F.
Martins, Alice Maria C.
Pinheiro, Marta Cristhiany C.
Sousa, Mariana S.
Bezerra, Fernando Schemelzer M.
Monocyte Chemotactic Protein-1 (MCP-1) in Patients with Chronic Schistosomiasis Mansoni: Evidences of Subclinical Renal Inflammation
title Monocyte Chemotactic Protein-1 (MCP-1) in Patients with Chronic Schistosomiasis Mansoni: Evidences of Subclinical Renal Inflammation
title_full Monocyte Chemotactic Protein-1 (MCP-1) in Patients with Chronic Schistosomiasis Mansoni: Evidences of Subclinical Renal Inflammation
title_fullStr Monocyte Chemotactic Protein-1 (MCP-1) in Patients with Chronic Schistosomiasis Mansoni: Evidences of Subclinical Renal Inflammation
title_full_unstemmed Monocyte Chemotactic Protein-1 (MCP-1) in Patients with Chronic Schistosomiasis Mansoni: Evidences of Subclinical Renal Inflammation
title_short Monocyte Chemotactic Protein-1 (MCP-1) in Patients with Chronic Schistosomiasis Mansoni: Evidences of Subclinical Renal Inflammation
title_sort monocyte chemotactic protein-1 (mcp-1) in patients with chronic schistosomiasis mansoni: evidences of subclinical renal inflammation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827226/
https://www.ncbi.nlm.nih.gov/pubmed/24265821
http://dx.doi.org/10.1371/journal.pone.0080421
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