Targeted Gene Therapy of Xeroderma Pigmentosum Cells Using Meganuclease and TALEN™

Xeroderma pigmentosum group C (XP-C) is a rare human syndrome characterized by hypersensitivity to UV light and a dramatic predisposition to skin neoplasms. XP-C cells are deficient in the nucleotide excision repair (NER) pathway, a complex process involved in the recognition and removal of DNA lesi...

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Detalles Bibliográficos
Autores principales: Dupuy, Aurélie, Valton, Julien, Leduc, Sophie, Armier, Jacques, Galetto, Roman, Gouble, Agnès, Lebuhotel, Céline, Stary, Anne, Pâques, Frédéric, Duchateau, Philippe, Sarasin, Alain, Daboussi, Fayza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827243/
https://www.ncbi.nlm.nih.gov/pubmed/24236034
http://dx.doi.org/10.1371/journal.pone.0078678

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