Cargando…

Preconditioning of Microglia by α-Synuclein Strongly Affects the Response Induced by Toll-like Receptor (TLR) Stimulation

In recent years, it has become accepted that α-synuclein (αSyn) has a key role in the microglia-mediated neuroinflammation, which accompanies the development of Parkinson’s disease and other related disorders, such as Dementia with Lewy Bodies and Alzheimer’s disease. Nevertheless, the cellular and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roodveldt, Cintia, Labrador-Garrido, Adahir, Gonzalez-Rey, Elena, Lachaud, Christian C., Guilliams, Tim, Fernandez-Montesinos, Rafael, Benitez-Rondan, Alicia, Robledo, Gema, Hmadcha, Abdelkrim, Delgado, Mario, Dobson, Christopher M., Pozo, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827304/ https://www.ncbi.nlm.nih.gov/pubmed/24236103 http://dx.doi.org/10.1371/journal.pone.0079160

Ejemplares similares

Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked Mutants
por: Roodveldt, Cintia, et al.
Publicado: (2010)

Chaperoned amyloid proteins for immune manipulation: α-Synuclein/Hsp70 shifts immunity toward a modulatory phenotype
por: Labrador-Garrido, Adahir, et al.
Publicado: (2014)

Immunological features of α-synuclein in Parkinson's disease
por: Roodveldt, Cintia, et al.
Publicado: (2008)

A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology
por: Chedid, Jessica, et al.
Publicado: (2022)

Use of Mesothelial Cells and Biological Matrices for Tissue Engineering of Simple Epithelium Surrogates
por: Lachaud, Christian Claude, et al.
Publicado: (2015)

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
por: Fellner, Lisa, et al.
Publicado: (2013)

Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations
por: Labrador-Garrido, Adahir, et al.
Publicado: (2023)

Functional Vascular Smooth Muscle-like Cells Derived from Adult Mouse Uterine Mesothelial Cells
por: Lachaud, Christian Claude, et al.
Publicado: (2013)

Distinct responses of human peripheral blood cells to different misfolded protein oligomers
por: Leal‐Lasarte, Magdalena, et al.
Publicado: (2021)

The chaperonin CCT inhibits assembly of α-synuclein amyloid fibrils by a specific, conformation-dependent interaction
por: Sot, Begoña, et al.
Publicado: (2017)

The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system
por: Kuter, Katarzyna Z., et al.
Publicado: (2021)

Resveratrol Ameliorates the Maturation Process of β-Cell-Like Cells Obtained from an Optimized Differentiation Protocol of Human Embryonic Stem Cells
por: Pezzolla, Daniela, et al.
Publicado: (2015)

Commentary: Immunochemical Markers of the Amyloid Cascade in the Hippocampus in Motor Neuron Diseases
por: Johnson, Ian Paul, et al.
Publicado: (2017)

Microglia as modulators of exosomal alpha-synuclein transmission
por: Xia, Yun, et al.
Publicado: (2019)

Toll-like receptor stimulation differentially regulates vasoactive intestinal peptide type 2 receptor in macrophages
por: Herrera, Juan Luis, et al.
Publicado: (2009)

α-Synuclein Alters Toll-Like Receptor Expression
por: Béraud, Dawn, et al.
Publicado: (2011)

miR-7 Modulates hESC Differentiation into Insulin-Producing Beta-like Cells and Contributes to Cell Maturation
por: López-Beas, Javier, et al.
Publicado: (2018)

Human Omental Mesothelial Cells Impart an Immunomodulatory Landscape Impeding B- and T-Cell Activation
por: Gauthier, Benoit R., et al.
Publicado: (2022)

The Interplay between α-Synuclein and Microglia in α-Synucleinopathies
por: Deyell, Jacob S., et al.
Publicado: (2023)

Microglia Response During Parkinson’s Disease: Alpha-Synuclein Intervention
por: Ferreira, Sara A., et al.
Publicado: (2018)

Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease
por: George, Sonia, et al.
Publicado: (2019)

Microglia preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic rats
por: Kanazawa, Masato, et al.
Publicado: (2017)

EGF-induced adipose tissue mesothelial cells undergo functional vascular smooth muscle differentiation
por: Lachaud, C C, et al.
Publicado: (2014)

Editorial: Molecular Chaperones and Neurodegeneration
por: Roodveldt, Cintia, et al.
Publicado: (2017)

Function and mechanism of toll-like receptors in cerebral ischemic tolerance: from preconditioning to treatment
por: Wang, Peng-Fei, et al.
Publicado: (2015)

Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect
por: Scheid, Stefanie, et al.
Publicado: (2022)

Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease Risk
por: Booms, Alix, et al.
Publicado: (2021)

Methylation-Dependent Gene Silencing Induced by Interleukin 1β via Nitric Oxide Production
por: Hmadcha, Abdelkrim, et al.
Publicado: (1999)

Toll-Like Receptor (TLR2 and TLR4) Polymorphisms and Chronic Obstructive Pulmonary Disease
por: Budulac, Simona E., et al.
Publicado: (2012)

Expression of Toll-Like Receptors (TLR2 and TLR4) in the Eyes of Mice with Disseminated Acanthamoebiasis
por: Kot, Karolina, et al.
Publicado: (2019)

TLR2 and TLR4 in Parkinson’s disease pathogenesis: the environment takes a toll on the gut
por: Gorecki, Anastazja M., et al.
Publicado: (2021)

Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation
por: Derkow, Katja, et al.
Publicado: (2015)

Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia
por: Yao, Linli, et al.
Publicado: (2013)

Preconditioning of Rat Bone Marrow-Derived Mesenchymal Stromal Cells with Toll-Like Receptor Agonists
por: Evaristo-Mendonça, Fabiana, et al.
Publicado: (2019)

Toll-Like Receptor 9 Is Required for Opioid-Induced Microglia Apoptosis
por: He, Lei, et al.
Publicado: (2011)

Preconditioning and parallel preconditioning
por: Duff, I S, et al.
Publicado: (1998)

Toll-Like Receptor (TLR) 2 and TLR4 Differentially Regulate Doxorubicin Induced Cardiomyopathy in Mice
por: Ma, Yonggang, et al.
Publicado: (2012)

Clinical Implication of Toll-Like Receptors (TLR2 and TLR4) in Acute Myeloid Leukemia Patients
por: Aref, Salah, et al.
Publicado: (2020)

Erratum to “Preconditioning of Rat Bone Marrow-Derived Mesenchymal Stromal Cells with Toll-Like Receptor Agonists”
por: Evaristo-Mendonça, Fabiana, et al.
Publicado: (2020)

Impact of III-Nitride/Si Interface Preconditioning on Breakdown Voltage in GaN-on-Silicon HEMT
por: Khediri, Abdelkrim, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_j1gpinedk4oqtkbt0rrclmap9j