The Tuberculosis Vaccine Candidate Bacillus Calmette-Guérin ΔureC::hly Coexpressing Human Interleukin-7 or -18 Enhances Antigen-Specific T Cell Responses in Mice

Bacillus Calmette–Guérin (BCG), the only approved tuberculosis vaccine, provides only limited protection. Previously, we generated a recombinant derivative (BCG ΔureC::hly), which secretes the pore-forming toxin listeriolysin O (LLO) of Listeria monocytogenes. This vaccine shows superior protection...

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Detalles Bibliográficos
Autores principales: Rao, Martin, Vogelzang, Alexis, Kaiser, Peggy, Schuerer, Stefanie, Kaufmann, Stefan H. E., Gengenbacher, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827306/
https://www.ncbi.nlm.nih.gov/pubmed/24236077
http://dx.doi.org/10.1371/journal.pone.0078966

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