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Increased Numbers of Circulating CD8 Effector Memory T Cells before Transplantation Enhance the Risk of Acute Rejection in Lung Transplant Recipients

The effector and regulatory T cell subpopulations involved in the development of acute rejection episodes in lung transplantation remain to be elucidated. Twenty-seven lung transplant candidates were prospectively monitored before transplantation and within the first year post-transplantation. Regul...

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Autores principales: San Segundo, David, Ballesteros, María Ángeles, Naranjo, Sara, Zurbano, Felipe, Miñambres, Eduardo, López-Hoyos, Marcos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827433/
https://www.ncbi.nlm.nih.gov/pubmed/24236187
http://dx.doi.org/10.1371/journal.pone.0080601
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author San Segundo, David
Ballesteros, María Ángeles
Naranjo, Sara
Zurbano, Felipe
Miñambres, Eduardo
López-Hoyos, Marcos
author_facet San Segundo, David
Ballesteros, María Ángeles
Naranjo, Sara
Zurbano, Felipe
Miñambres, Eduardo
López-Hoyos, Marcos
author_sort San Segundo, David
collection PubMed
description The effector and regulatory T cell subpopulations involved in the development of acute rejection episodes in lung transplantation remain to be elucidated. Twenty-seven lung transplant candidates were prospectively monitored before transplantation and within the first year post-transplantation. Regulatory, Th17, memory and naïve T cells were measured in peripheral blood of lung transplant recipients by flow cytometry. No association of acute rejection with number of peripheral regulatory T cells and Th17 cells was found. However, effector memory subsets in acute rejection patients were increased during the first two months post-transplant. Interestingly, patients waiting for lung transplant with levels of CD8(+) effector memory T cells over 185 cells/mm(3) had a significant increased risk of rejection [OR: 5.62 (95% CI: 1.08-29.37), p=0.04]. In multivariate analysis adjusted for age and gender the odds ratio for rejection was: OR: 5.89 (95% CI: 1.08-32.24), p=0.04. These data suggest a correlation between acute rejection and effector memory T cells in lung transplant recipients. The measurement of peripheral blood CD8(+) effector memory T cells prior to lung transplant may define patients at high risk of acute lung rejection.
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spelling pubmed-38274332013-11-14 Increased Numbers of Circulating CD8 Effector Memory T Cells before Transplantation Enhance the Risk of Acute Rejection in Lung Transplant Recipients San Segundo, David Ballesteros, María Ángeles Naranjo, Sara Zurbano, Felipe Miñambres, Eduardo López-Hoyos, Marcos PLoS One Research Article The effector and regulatory T cell subpopulations involved in the development of acute rejection episodes in lung transplantation remain to be elucidated. Twenty-seven lung transplant candidates were prospectively monitored before transplantation and within the first year post-transplantation. Regulatory, Th17, memory and naïve T cells were measured in peripheral blood of lung transplant recipients by flow cytometry. No association of acute rejection with number of peripheral regulatory T cells and Th17 cells was found. However, effector memory subsets in acute rejection patients were increased during the first two months post-transplant. Interestingly, patients waiting for lung transplant with levels of CD8(+) effector memory T cells over 185 cells/mm(3) had a significant increased risk of rejection [OR: 5.62 (95% CI: 1.08-29.37), p=0.04]. In multivariate analysis adjusted for age and gender the odds ratio for rejection was: OR: 5.89 (95% CI: 1.08-32.24), p=0.04. These data suggest a correlation between acute rejection and effector memory T cells in lung transplant recipients. The measurement of peripheral blood CD8(+) effector memory T cells prior to lung transplant may define patients at high risk of acute lung rejection. Public Library of Science 2013-11-13 /pmc/articles/PMC3827433/ /pubmed/24236187 http://dx.doi.org/10.1371/journal.pone.0080601 Text en © 2013 San Segundo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
San Segundo, David
Ballesteros, María Ángeles
Naranjo, Sara
Zurbano, Felipe
Miñambres, Eduardo
López-Hoyos, Marcos
Increased Numbers of Circulating CD8 Effector Memory T Cells before Transplantation Enhance the Risk of Acute Rejection in Lung Transplant Recipients
title Increased Numbers of Circulating CD8 Effector Memory T Cells before Transplantation Enhance the Risk of Acute Rejection in Lung Transplant Recipients
title_full Increased Numbers of Circulating CD8 Effector Memory T Cells before Transplantation Enhance the Risk of Acute Rejection in Lung Transplant Recipients
title_fullStr Increased Numbers of Circulating CD8 Effector Memory T Cells before Transplantation Enhance the Risk of Acute Rejection in Lung Transplant Recipients
title_full_unstemmed Increased Numbers of Circulating CD8 Effector Memory T Cells before Transplantation Enhance the Risk of Acute Rejection in Lung Transplant Recipients
title_short Increased Numbers of Circulating CD8 Effector Memory T Cells before Transplantation Enhance the Risk of Acute Rejection in Lung Transplant Recipients
title_sort increased numbers of circulating cd8 effector memory t cells before transplantation enhance the risk of acute rejection in lung transplant recipients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827433/
https://www.ncbi.nlm.nih.gov/pubmed/24236187
http://dx.doi.org/10.1371/journal.pone.0080601
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