Cargando…

Prognostic Importance and Therapeutic Implications of PAK1, a Drugable Protein Kinase, in Gastroesophageal Junction Adenocarcinoma

Gastroesophageal junction (GEJ) adenocarcinoma is a lethal cancer with rising incidence, yet the molecular biomarkers that have strong prognostic impact and also hold great therapeutic promise remain elusive. We used a data mining approach and identified the p21 protein-activated kinase 1 (PAK1), an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Zongtai, Zou, Xiaofang, Xie, Liangxi, Dong, Hongmei, Chen, Yuping, Liu, Qing, Wu, Xiao, Zhou, David, Tan, Dongfeng, Zhang, Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827444/ https://www.ncbi.nlm.nih.gov/pubmed/24236193 http://dx.doi.org/10.1371/journal.pone.0080665

Ejemplares similares

Emerging Role of Tyrosine Kinases as Drugable Targets in Cancer
por: Na, Il-Kang, et al.
Publicado: (2015)

The Metastasis-Associated Gene MTA3, a Component of the Mi-2/NuRD Transcriptional Repression Complex, Predicts Prognosis of Gastroesophageal Junction Adenocarcinoma
por: Dong, Hongmei, et al.
Publicado: (2013)

Expression and Prognostic Value of RAD51 in Adenocarcinoma at the Gastroesophageal Junction
por: Redati, Darebai, et al.
Publicado: (2022)

Platelets as a prognostic factor for patients with adenocarcinoma of the gastroesophageal junction
por: Feka, Joy, et al.
Publicado: (2023)

The expressions and prognostic implications of Twist and E-cadherin in adenocarcinomas of the gastroesophageal junction and proximal gastric carcinoma
por: Sun, Shengbo, et al.
Publicado: (2019)

Gastroesophageal junction adenocarcinoma metastasizing to gingiva
por: Masamatti, Smita S, et al.
Publicado: (2013)

Epidemiology of Gastroesophageal Junction Adenocarcinoma in Korea
por: Kim, Jin-Jo
Publicado: (2018)

Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei
por: Urbaniak, Michael D., et al.
Publicado: (2012)

Reaching Un-Drugable Intracellular Targets with the Long Arm of Antibodies
por: Scheinberg, David A., et al.
Publicado: (2013)

Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer
por: Amatu, Alessio, et al.
Publicado: (2015)

Independent Stage Classification for Gastroesophageal Junction Adenocarcinoma
por: Hirata, Yuki, et al.
Publicado: (2023)

Long-Term Survival in Gastroesophageal Junction Adenocarcinoma: Ramucirumab
por: Gil-Delgado, Maria Angeles, et al.
Publicado: (2018)

Treatment for metastatic adenocarcinoma of the stomach and gastroesophageal junction: 2020
por: Hsu, Andrew, et al.
Publicado: (2020)

Treatment Patterns for Gastroesophageal Junction Adenocarcinoma in the United States †
por: Kim, Bradford J., et al.
Publicado: (2020)

Adenocarcinoma of the Gastroesophageal Junction Masquerading as Mallory-Weiss Syndrome
por: Okamoto, Takeshi, et al.
Publicado: (2022)

Mediastinal Lymph Node Dissection in Gastroesophageal Junction Adenocarcinoma
por: Kim, Jin-Jo
Publicado: (2023)

Glutamine Synthetase Drugability beyond Its Active Site: Exploring Oligomerization Interfaces and Pockets
por: Moreira, Cátia, et al.
Publicado: (2016)

Meningeal Carcinomatosis: A Metastasis from Gastroesophageal Junction Adenocarcinoma
por: Dam, Tanya, et al.
Publicado: (2013)

Incidence of Microscopically Positive Proximal Margins in Adenocarcinoma of the Gastroesophageal Junction
por: Gao, Fei, et al.
Publicado: (2014)

Signaling pathways in the molecular pathogenesis of adenocarcinomas of the esophagus and gastroesophageal junction
por: Clemons, Nicholas J, et al.
Publicado: (2013)

Isolated Splenic Metastases of Her2+++ Gastroesophageal Junction Adenocarcinoma
por: Sigrand, Julie, et al.
Publicado: (2016)

Genomic similarity between gastroesophageal junction and esophageal Barrett's adenocarcinomas
por: Ferrer-Torres, Daysha, et al.
Publicado: (2016)

Evolving Management Strategies for Metastatic Esophageal and Gastroesophageal Junction Adenocarcinoma
por: Das, Satya, et al.
Publicado: (2018)

ASO Author Reflections: Challenges in the Management of Gastroesophageal Junctional Adenocarcinoma
por: Kamarajah, Sivesh K., et al.
Publicado: (2021)

Midesophageal Metastatic Disease After Treatment of Gastroesophageal Junction Adenocarcinoma
por: Brotherton, Tim, et al.
Publicado: (2022)

Gastroesophageal junction adenocarcinoma 1-year after sleeve gastrectomy
por: Brown, Kevin C, et al.
Publicado: (2023)

Surgical pathology of adenocarcinomas arising around or within the gastroesophageal junction
por: Dislich, Bastian, et al.
Publicado: (2022)

Refined expression quantitative trait locus analysis on adenocarcinoma at the gastroesophageal junction reveals susceptibility and prognostic markers
por: Zhong, Ce, et al.
Publicado: (2023)

ATM Germline-Mutated Gastroesophageal Junction Adenocarcinomas: Clinical Descriptors, Molecular Characteristics, and Potential Therapeutic Implications
por: El Jabbour, Tony, et al.
Publicado: (2022)

Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening
por: Miglianico, Marie, et al.
Publicado: (2023)

MET tyrosine kinase receptor expression and amplification as prognostic biomarkers of survival in gastroesophageal adenocarcinoma
por: Catenacci, Daniel V. T., et al.
Publicado: (2016)

Irinotecan, docetaxel and oxaliplatin combination in metastatic gastric or gastroesophageal junction adenocarcinoma
por: Di Lauro, L, et al.
Publicado: (2007)

Results of postoperative radiochemotherapy of the patients with resectable gastroesophageal junction adenocarcinoma in Slovenia
por: Jeromen, Ana, et al.
Publicado: (2012)

Genetic Polymorphisms at TIMP3 Are Associated with Survival of Adenocarcinoma of the Gastroesophageal Junction
por: Bashash, Morteza, et al.
Publicado: (2013)

Concurrent Neoadjuvant Chemoradiotherapy for Siewert II and III Adenocarcinoma at Gastroesophageal Junction
por: Zhao, Qun, et al.
Publicado: (2015)

Positioning of second‐line treatment for advanced gastric and gastroesophageal junction adenocarcinoma
por: Pericay, Carles, et al.
Publicado: (2016)

Transcriptomic profiling reveals three molecular phenotypes of adenocarcinoma at the gastroesophageal junction
por: Bornschein, Jan, et al.
Publicado: (2019)

Paraneoplastic Leukemoid Reaction in Gastroesophageal Junction Adenocarcinoma: A Case Report
por: Chang*, Kevin Wei-Lun, et al.
Publicado: (2020)

The Role of Cancer Stem Cells in Drug Resistance in Gastroesophageal Junction Adenocarcinoma
por: Dinneen, Kate, et al.
Publicado: (2021)

Identification of Sensitivity Predictors of Neoadjuvant Chemotherapy for the Treatment of Adenocarcinoma of Gastroesophageal Junction
por: Li, Shoumiao, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_fpr31676vtkjcqqcbgtv5itrdc