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к Opioids inhibit tumor angiogenesis by suppressing VEGF signaling

Opioids are effective analgesics for the management of moderate to severe cancer pain. Here we show that κ opioid receptor (KOR) agonists act as anti-angiogenic factors in tumors. Treatment with KOR agonists, U50,488H and TRK820, significantly inhibited human umbilical vein endothelial cell (HUVEC)...

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Detalles Bibliográficos
Autores principales:	Yamamizu, Kohei, Furuta, Sadayoshi, Hamada, Yusuke, Yamashita, Akira, Kuzumaki, Naoko, Narita, Michiko, Doi, Kento, Katayama, Shiori, Nagase, Hiroshi, Yamashita, Jun K., Narita, Minoru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827603/ https://www.ncbi.nlm.nih.gov/pubmed/24225480 http://dx.doi.org/10.1038/srep03213

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