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Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress

Aberrant DNA hypermethylation is frequently found in tumor cells and inhibition of DNA methylation is an effective anticancer strategy. In this study, the therapeutic effect of DNA methyltransferase (DNMT) inhibitor zebularine (Zeb) on colorectal cancer (CRC) was investigated. Zeb exhibited anticanc...

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Detalles Bibliográficos
Autores principales:	Yang, Pei-Ming, Lin, Yi-Ting, Shun, Chia-Tung, Lin, Shan-Hu, Wei, Tzu-Tang, Chuang, Shu-Hui, Wu, Ming-Shiang, Chen, Ching-Chow
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827606/ https://www.ncbi.nlm.nih.gov/pubmed/24225777 http://dx.doi.org/10.1038/srep03219

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