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Long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinoma

BACKGROUND: Vascular abnormalities are the predominant histologic changes associated with radiation in nasopharyngeal carcinoma (NPC). This study examined if the duration after radiotherapy correlates with the progression of carotid intima-media thickness (IMT) and investigated its relationship with...

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Autores principales: Huang, Tai-Lin, Hsu, Hsuan-Chih, Chen, Hui-Chun, Lin, Hsin-Ching, Chien, Chih-Yen, Fang, Fu-Min, Huang, Chih-Cheng, Chang, Hsueh-Wen, Chang, Wen-Neng, Huang, Chi-Ren, Tsai, Nai-Wen, Kung, Chia-Te, Wang, Hung-Chen, Lin, Wei-Che, Cheng, Ben-Chung, Su, Yu-Jih, Chang, Ya-Ting, Chang, Chuang-Rung, Tan, Teng-Yeow, Lu, Cheng-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827874/
https://www.ncbi.nlm.nih.gov/pubmed/24196030
http://dx.doi.org/10.1186/1748-717X-8-261
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author Huang, Tai-Lin
Hsu, Hsuan-Chih
Chen, Hui-Chun
Lin, Hsin-Ching
Chien, Chih-Yen
Fang, Fu-Min
Huang, Chih-Cheng
Chang, Hsueh-Wen
Chang, Wen-Neng
Huang, Chi-Ren
Tsai, Nai-Wen
Kung, Chia-Te
Wang, Hung-Chen
Lin, Wei-Che
Cheng, Ben-Chung
Su, Yu-Jih
Chang, Ya-Ting
Chang, Chuang-Rung
Tan, Teng-Yeow
Lu, Cheng-Hsien
author_facet Huang, Tai-Lin
Hsu, Hsuan-Chih
Chen, Hui-Chun
Lin, Hsin-Ching
Chien, Chih-Yen
Fang, Fu-Min
Huang, Chih-Cheng
Chang, Hsueh-Wen
Chang, Wen-Neng
Huang, Chi-Ren
Tsai, Nai-Wen
Kung, Chia-Te
Wang, Hung-Chen
Lin, Wei-Che
Cheng, Ben-Chung
Su, Yu-Jih
Chang, Ya-Ting
Chang, Chuang-Rung
Tan, Teng-Yeow
Lu, Cheng-Hsien
author_sort Huang, Tai-Lin
collection PubMed
description BACKGROUND: Vascular abnormalities are the predominant histologic changes associated with radiation in nasopharyngeal carcinoma (NPC). This study examined if the duration after radiotherapy correlates with the progression of carotid intima-media thickness (IMT) and investigated its relationship with inflammatory markers. METHODS: One hundred and five NPC patients post-radiotherapy for more than one year and 25 healthy control subjects were examined by B-mode ultrasound for IMT measurement at the far wall of the common carotid artery (CCA). Surrogate markers including lipid profile, HbA1c, and high sensitive C-reactive protein (hs-CRP) were assessed. RESULTS: The IMT of CCA was significantly increased in NPC patients and carotid plaque was detected in 38 NPC patients (38/105, 36.2%). Significant risk factors for carotid plaques included age, duration after radiotherapy, and HbA1c levels. Age, duration after radiotherapy, hs-CRP, HbA1c, and platelet count positively correlated with IMT. The cut-off value of age and duration after radiotherapy for the presence of plaque was 52.5 years and 42.5 months, respectively. In NPC subjects, multiple linear regression analysis revealed that age, gender, duration after radiotherapy and platelet counts were independently associated with CCA IMT. After adjustments for age, gender and platelet counts, IMT increased in a linear manner with duration after radiotherapy. CONCLUSIONS: Radiation-induced vasculopathy is a dynamic and progressive process due to late radiation effects. Extra-cranial color-coded duplex sonography can be part of routine follow-up in NPC patients aged ≥50 years at 40 months post-radiotherapy.
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spelling pubmed-38278742013-11-15 Long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinoma Huang, Tai-Lin Hsu, Hsuan-Chih Chen, Hui-Chun Lin, Hsin-Ching Chien, Chih-Yen Fang, Fu-Min Huang, Chih-Cheng Chang, Hsueh-Wen Chang, Wen-Neng Huang, Chi-Ren Tsai, Nai-Wen Kung, Chia-Te Wang, Hung-Chen Lin, Wei-Che Cheng, Ben-Chung Su, Yu-Jih Chang, Ya-Ting Chang, Chuang-Rung Tan, Teng-Yeow Lu, Cheng-Hsien Radiat Oncol Research BACKGROUND: Vascular abnormalities are the predominant histologic changes associated with radiation in nasopharyngeal carcinoma (NPC). This study examined if the duration after radiotherapy correlates with the progression of carotid intima-media thickness (IMT) and investigated its relationship with inflammatory markers. METHODS: One hundred and five NPC patients post-radiotherapy for more than one year and 25 healthy control subjects were examined by B-mode ultrasound for IMT measurement at the far wall of the common carotid artery (CCA). Surrogate markers including lipid profile, HbA1c, and high sensitive C-reactive protein (hs-CRP) were assessed. RESULTS: The IMT of CCA was significantly increased in NPC patients and carotid plaque was detected in 38 NPC patients (38/105, 36.2%). Significant risk factors for carotid plaques included age, duration after radiotherapy, and HbA1c levels. Age, duration after radiotherapy, hs-CRP, HbA1c, and platelet count positively correlated with IMT. The cut-off value of age and duration after radiotherapy for the presence of plaque was 52.5 years and 42.5 months, respectively. In NPC subjects, multiple linear regression analysis revealed that age, gender, duration after radiotherapy and platelet counts were independently associated with CCA IMT. After adjustments for age, gender and platelet counts, IMT increased in a linear manner with duration after radiotherapy. CONCLUSIONS: Radiation-induced vasculopathy is a dynamic and progressive process due to late radiation effects. Extra-cranial color-coded duplex sonography can be part of routine follow-up in NPC patients aged ≥50 years at 40 months post-radiotherapy. BioMed Central 2013-11-07 /pmc/articles/PMC3827874/ /pubmed/24196030 http://dx.doi.org/10.1186/1748-717X-8-261 Text en Copyright © 2013 Huang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Huang, Tai-Lin
Hsu, Hsuan-Chih
Chen, Hui-Chun
Lin, Hsin-Ching
Chien, Chih-Yen
Fang, Fu-Min
Huang, Chih-Cheng
Chang, Hsueh-Wen
Chang, Wen-Neng
Huang, Chi-Ren
Tsai, Nai-Wen
Kung, Chia-Te
Wang, Hung-Chen
Lin, Wei-Che
Cheng, Ben-Chung
Su, Yu-Jih
Chang, Ya-Ting
Chang, Chuang-Rung
Tan, Teng-Yeow
Lu, Cheng-Hsien
Long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinoma
title Long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinoma
title_full Long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinoma
title_fullStr Long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinoma
title_full_unstemmed Long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinoma
title_short Long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinoma
title_sort long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827874/
https://www.ncbi.nlm.nih.gov/pubmed/24196030
http://dx.doi.org/10.1186/1748-717X-8-261
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