Novel preclinical models of topical PrEP pharmacodynamics provide rationale for combination of drugs with complementary properties

BACKGROUND: The limited success of recent HIV topical pre-exposure prophylaxis clinical trials highlights the need for more predictive models of drug efficacy that better simulate what may happen during sexual exposure. To address this gap, we developed complementary in vitro models to evaluate the...

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Detalles Bibliográficos
Autores principales: Mesquita, Pedro MM, Srinivasan, Priya, Johnson, Todd J, Rastogi, Rachna, Evans-Strickfaden, Tammy, Kay, Michael S, Buckheit, Karen W, Buckheit Jr , Robert W, Smith, James M, Kiser, Patrick F, Herold, Betsy C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827994/
https://www.ncbi.nlm.nih.gov/pubmed/24156604
http://dx.doi.org/10.1186/1742-4690-10-113

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