Nonalcoholic fatty liver disease: molecular pathways and therapeutic strategies

Along with rising numbers of patients with metabolic syndrome, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased in proportion with the obesity epidemic. While there are no established treatments for NAFLD, current research is targeting new molecular mechanisms that underlie N...

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Autores principales: Huang, Yue Ye, Gusdon, Aaron M, Qu, Shen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827997/
https://www.ncbi.nlm.nih.gov/pubmed/24209497
http://dx.doi.org/10.1186/1476-511X-12-171
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author Huang, Yue Ye
Gusdon, Aaron M
Qu, Shen
author_facet Huang, Yue Ye
Gusdon, Aaron M
Qu, Shen
author_sort Huang, Yue Ye
collection PubMed
description Along with rising numbers of patients with metabolic syndrome, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased in proportion with the obesity epidemic. While there are no established treatments for NAFLD, current research is targeting new molecular mechanisms that underlie NAFLD and associated metabolic disorders. This review discusses some of these emerging molecular mechanisms and their therapeutic implications for the treatment of NAFLD. The basic research that has identified potential molecular targets for pharmacotherapy will be outlined.
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spelling pubmed-38279972013-11-15 Nonalcoholic fatty liver disease: molecular pathways and therapeutic strategies Huang, Yue Ye Gusdon, Aaron M Qu, Shen Lipids Health Dis Review Along with rising numbers of patients with metabolic syndrome, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased in proportion with the obesity epidemic. While there are no established treatments for NAFLD, current research is targeting new molecular mechanisms that underlie NAFLD and associated metabolic disorders. This review discusses some of these emerging molecular mechanisms and their therapeutic implications for the treatment of NAFLD. The basic research that has identified potential molecular targets for pharmacotherapy will be outlined. BioMed Central 2013-11-09 /pmc/articles/PMC3827997/ /pubmed/24209497 http://dx.doi.org/10.1186/1476-511X-12-171 Text en Copyright © 2013 Huang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Huang, Yue Ye
Gusdon, Aaron M
Qu, Shen
Nonalcoholic fatty liver disease: molecular pathways and therapeutic strategies
title Nonalcoholic fatty liver disease: molecular pathways and therapeutic strategies
title_full Nonalcoholic fatty liver disease: molecular pathways and therapeutic strategies
title_fullStr Nonalcoholic fatty liver disease: molecular pathways and therapeutic strategies
title_full_unstemmed Nonalcoholic fatty liver disease: molecular pathways and therapeutic strategies
title_short Nonalcoholic fatty liver disease: molecular pathways and therapeutic strategies
title_sort nonalcoholic fatty liver disease: molecular pathways and therapeutic strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827997/
https://www.ncbi.nlm.nih.gov/pubmed/24209497
http://dx.doi.org/10.1186/1476-511X-12-171
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