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A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System
Models of glucose metabolism are a valuable tool for fundamental and applied medical research in diabetes. Use cases range from pharmaceutical target selection to automatic blood glucose control. Standard compartmental models represent little biological detail, which hampers the integration of multi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828004/ https://www.ncbi.nlm.nih.gov/pubmed/23945606 http://dx.doi.org/10.1038/psp.2013.40 |
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author | Schaller, S Willmann, S Lippert, J Schaupp, L Pieber, T R Schuppert, A Eissing, T |
author_facet | Schaller, S Willmann, S Lippert, J Schaupp, L Pieber, T R Schuppert, A Eissing, T |
author_sort | Schaller, S |
collection | PubMed |
description | Models of glucose metabolism are a valuable tool for fundamental and applied medical research in diabetes. Use cases range from pharmaceutical target selection to automatic blood glucose control. Standard compartmental models represent little biological detail, which hampers the integration of multiscale data and confines predictive capabilities. We developed a detailed, generic physiologically based whole-body model of the glucose-insulin-glucagon regulatory system, reflecting detailed physiological properties of healthy populations and type 1 diabetes individuals expressed in the respective parameterizations. The model features a detailed representation of absorption models for oral glucose, subcutaneous insulin and glucagon, and an insulin receptor model relating pharmacokinetic properties to pharmacodynamic effects. Model development and validation is based on literature data. The quality of predictions is high and captures relevant observed inter- and intra-individual variability. In the generic form, the model can be applied to the development and validation of novel diabetes treatment strategies. |
format | Online Article Text |
id | pubmed-3828004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-38280042013-11-15 A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System Schaller, S Willmann, S Lippert, J Schaupp, L Pieber, T R Schuppert, A Eissing, T CPT Pharmacometrics Syst Pharmacol Original Article Models of glucose metabolism are a valuable tool for fundamental and applied medical research in diabetes. Use cases range from pharmaceutical target selection to automatic blood glucose control. Standard compartmental models represent little biological detail, which hampers the integration of multiscale data and confines predictive capabilities. We developed a detailed, generic physiologically based whole-body model of the glucose-insulin-glucagon regulatory system, reflecting detailed physiological properties of healthy populations and type 1 diabetes individuals expressed in the respective parameterizations. The model features a detailed representation of absorption models for oral glucose, subcutaneous insulin and glucagon, and an insulin receptor model relating pharmacokinetic properties to pharmacodynamic effects. Model development and validation is based on literature data. The quality of predictions is high and captures relevant observed inter- and intra-individual variability. In the generic form, the model can be applied to the development and validation of novel diabetes treatment strategies. Nature Publishing Group 2013-08 2013-08-14 /pmc/articles/PMC3828004/ /pubmed/23945606 http://dx.doi.org/10.1038/psp.2013.40 Text en Copyright © 2013 American Society for Clinical Pharmacology and Therapeutics http://creativecommons.org/licenses/by-nc-nd/3.0/ CPT: Pharmacometrics and Systems Pharmacology is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Original Article Schaller, S Willmann, S Lippert, J Schaupp, L Pieber, T R Schuppert, A Eissing, T A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System |
title | A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System |
title_full | A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System |
title_fullStr | A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System |
title_full_unstemmed | A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System |
title_short | A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System |
title_sort | generic integrated physiologically based whole-body model of the glucose-insulin-glucagon regulatory system |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828004/ https://www.ncbi.nlm.nih.gov/pubmed/23945606 http://dx.doi.org/10.1038/psp.2013.40 |
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