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Intracellular Interferons in Fish: A Unique Means to Combat Viral Infection

We demonstrate for the first time in vertebrates, that alternative splicing of interferon (IFN) genes can lead to a functional intracellular IFN (iIFN). Fish IFN genes possess introns and in rainbow trout three alternatively spliced transcripts of the IFN1 gene exist. Two of the encoded IFNs are pre...

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Detalles Bibliográficos
Autores principales:	Chang, Ming-Xian, Zou, Jun, Nie, Pin, Huang, Bei, Yu, Zhanglong, Collet, Bertrand, Secombes, Chris J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828176/ https://www.ncbi.nlm.nih.gov/pubmed/24244163 http://dx.doi.org/10.1371/journal.ppat.1003736

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