Identification of the Adenovirus E4orf4 Protein Binding Site on the B55α and Cdc55 Regulatory Subunits of PP2A: Implications for PP2A Function, Tumor Cell Killing and Viral Replication

Adenovirus E4orf4 protein induces the death of human cancer cells and Saccharomyces cerevisiae. Binding of E4orf4 to the B/B55/Cdc55 regulatory subunit of protein phosphatase 2A (PP2A) is required, and such binding inhibits PP2A(B55) activity leading to dose-dependent cell death. We found that E4orf...

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Detalles Bibliográficos
Autores principales: Mui, Melissa Z., Kucharski, Michael, Miron, Marie-Joëlle, Hur, Woosuk Steve, Berghuis, Albert M., Blanchette, Paola, Branton, Philip E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828177/
https://www.ncbi.nlm.nih.gov/pubmed/24244166
http://dx.doi.org/10.1371/journal.ppat.1003742

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