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Fischer Rats Consume 20% Ethanol in a Long-Term Intermittent-Access Two-Bottle-Choice Paradigm

The 20% ethanol intermittent-access (IAE) two-bottle-choice drinking procedure has been shown to produce high voluntary ethanol consumption in a number of rat strains. For this study, we applied this procedure to male Fischer (F344) rats, a strain previously reported to exhibit low levels of ethanol...

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Autores principales: Mill, Douglas J., Bito-Onon, Jade J., Simms, Jeffrey A., Li, Rui, Bartlett, Selena E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828209/
https://www.ncbi.nlm.nih.gov/pubmed/24244567
http://dx.doi.org/10.1371/journal.pone.0079824
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author Mill, Douglas J.
Bito-Onon, Jade J.
Simms, Jeffrey A.
Li, Rui
Bartlett, Selena E.
author_facet Mill, Douglas J.
Bito-Onon, Jade J.
Simms, Jeffrey A.
Li, Rui
Bartlett, Selena E.
author_sort Mill, Douglas J.
collection PubMed
description The 20% ethanol intermittent-access (IAE) two-bottle-choice drinking procedure has been shown to produce high voluntary ethanol consumption in a number of rat strains. For this study, we applied this procedure to male Fischer (F344) rats, a strain previously reported to exhibit low levels of ethanol consumption. We also subjected these animals to a two-week ethanol-deprivation-period to see if they would exhibit an alcohol deprivation effect (ADE) signified by a transient increase in alcohol consumption following deprivation. Our data show a separation between high and low consuming animals within this strain, with high-consumers exhibiting an escalation in consumption. In contrast, Fischer rats did not show a significant separation between high and low consumers or any significant escalation in consumption, using the 20% ethanol continuous-access two-bottle-choice drinking protocol. Following the two-week deprivation period, animals in the high (but not the low) IAE group exhibited the transient increase in ethanol consumption and preference typically associated with an ADE. Together, the data suggest that the intermittent access protocol is a useful protocol for increasing ethanol consumption.
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spelling pubmed-38282092013-11-16 Fischer Rats Consume 20% Ethanol in a Long-Term Intermittent-Access Two-Bottle-Choice Paradigm Mill, Douglas J. Bito-Onon, Jade J. Simms, Jeffrey A. Li, Rui Bartlett, Selena E. PLoS One Research Article The 20% ethanol intermittent-access (IAE) two-bottle-choice drinking procedure has been shown to produce high voluntary ethanol consumption in a number of rat strains. For this study, we applied this procedure to male Fischer (F344) rats, a strain previously reported to exhibit low levels of ethanol consumption. We also subjected these animals to a two-week ethanol-deprivation-period to see if they would exhibit an alcohol deprivation effect (ADE) signified by a transient increase in alcohol consumption following deprivation. Our data show a separation between high and low consuming animals within this strain, with high-consumers exhibiting an escalation in consumption. In contrast, Fischer rats did not show a significant separation between high and low consumers or any significant escalation in consumption, using the 20% ethanol continuous-access two-bottle-choice drinking protocol. Following the two-week deprivation period, animals in the high (but not the low) IAE group exhibited the transient increase in ethanol consumption and preference typically associated with an ADE. Together, the data suggest that the intermittent access protocol is a useful protocol for increasing ethanol consumption. Public Library of Science 2013-11-14 /pmc/articles/PMC3828209/ /pubmed/24244567 http://dx.doi.org/10.1371/journal.pone.0079824 Text en © 2013 Mill et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Mill, Douglas J.
Bito-Onon, Jade J.
Simms, Jeffrey A.
Li, Rui
Bartlett, Selena E.
Fischer Rats Consume 20% Ethanol in a Long-Term Intermittent-Access Two-Bottle-Choice Paradigm
title Fischer Rats Consume 20% Ethanol in a Long-Term Intermittent-Access Two-Bottle-Choice Paradigm
title_full Fischer Rats Consume 20% Ethanol in a Long-Term Intermittent-Access Two-Bottle-Choice Paradigm
title_fullStr Fischer Rats Consume 20% Ethanol in a Long-Term Intermittent-Access Two-Bottle-Choice Paradigm
title_full_unstemmed Fischer Rats Consume 20% Ethanol in a Long-Term Intermittent-Access Two-Bottle-Choice Paradigm
title_short Fischer Rats Consume 20% Ethanol in a Long-Term Intermittent-Access Two-Bottle-Choice Paradigm
title_sort fischer rats consume 20% ethanol in a long-term intermittent-access two-bottle-choice paradigm
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828209/
https://www.ncbi.nlm.nih.gov/pubmed/24244567
http://dx.doi.org/10.1371/journal.pone.0079824
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