Vascular Immunotargeting to Endothelial Determinant ICAM-1 Enables Optimal Partnering of Recombinant scFv-Thrombomodulin Fusion with Endogenous Cofactor

The use of targeted therapeutics to replenish pathologically deficient proteins on the luminal endothelial membrane has the potential to revolutionize emergency and cardiovascular medicine. Untargeted recombinant proteins, like activated protein C (APC) and thrombomodulin (TM), have demonstrated ben...

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Detalles Bibliográficos
Autores principales: Greineder, Colin F., Chacko, Ann-Marie, Zaytsev, Sergei, Zern, Blaine J., Carnemolla, Ronald, Hood, Elizabeth D., Han, Jingyan, Ding, Bi-Sen, Esmon, Charles T., Muzykantov, Vladimir R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828233/
https://www.ncbi.nlm.nih.gov/pubmed/24244621
http://dx.doi.org/10.1371/journal.pone.0080110

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