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Simvastatin Alleviates Hyperpermeability of Glomerular Endothelial Cells in Early-Stage Diabetic Nephropathy by Inhibition of RhoA/ROCK1
BACKGROUND: Endothelial dysfunction is an early sign of diabetic cardiovascular disease and may contribute to progressive diabetic nephropathy (DN). There is increasing evidence that dysfunction of the endothelial tight junction is a crucial step in the development of endothelial hyperpermeability,...
Autores principales: | Peng, Hui, Luo, Pengli, Li, Yuanqing, Wang, Cheng, Liu, Xun, Ye, Zengchun, Li, Canming, Lou, Tanqi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828237/ https://www.ncbi.nlm.nih.gov/pubmed/24244596 http://dx.doi.org/10.1371/journal.pone.0080009 |
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