Loss of Leucine-Rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs

The objective of this study was to evaluate the pathology time course of the LRRK2 knockout rat model of Parkinson’s disease at 1-, 2-, 4-, 8-, 12-, and 16-months of age. The evaluation consisted of histopathology and ultrastructure examination of selected organs, including the kidneys, lungs, splee...

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Detalles Bibliográficos
Autores principales: Baptista, Marco A. S., Dave, Kuldip D., Frasier, Mark A., Sherer, Todd B., Greeley, Melanie, Beck, Melissa J., Varsho, Julie S., Parker, George A., Moore, Cindy, Churchill, Madeline J., Meshul, Charles K., Fiske, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828242/
https://www.ncbi.nlm.nih.gov/pubmed/24244710
http://dx.doi.org/10.1371/journal.pone.0080705

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