Fhit Deficiency-Induced Global Genome Instability Promotes Mutation and Clonal Expansion

Loss of Fhit expression, encoded at chromosome fragile site FRA3B, leads to increased replication stress, genome instability and accumulation of genetic alterations. We have proposed that Fhit is a genome ‘caretaker’ whose loss initiates genome instability in preneoplastic lesions. We have character...

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Detalles Bibliográficos
Autores principales: Miuma, Satoshi, Saldivar, Joshua C., Karras, Jenna R., Waters, Catherine E., Paisie, Carolyn A., Wang, Yao, Jin, Victor, Sun, Jin, Druck, Teresa, Zhang, Jie, Huebner, Kay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828255/
https://www.ncbi.nlm.nih.gov/pubmed/24244712
http://dx.doi.org/10.1371/journal.pone.0080730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828255/
https://www.ncbi.nlm.nih.gov/pubmed/24244712
http://dx.doi.org/10.1371/journal.pone.0080730

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