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Fhit Deficiency-Induced Global Genome Instability Promotes Mutation and Clonal Expansion
Loss of Fhit expression, encoded at chromosome fragile site FRA3B, leads to increased replication stress, genome instability and accumulation of genetic alterations. We have proposed that Fhit is a genome ‘caretaker’ whose loss initiates genome instability in preneoplastic lesions. We have character...
Autores principales: | Miuma, Satoshi, Saldivar, Joshua C., Karras, Jenna R., Waters, Catherine E., Paisie, Carolyn A., Wang, Yao, Jin, Victor, Sun, Jin, Druck, Teresa, Zhang, Jie, Huebner, Kay |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828255/ https://www.ncbi.nlm.nih.gov/pubmed/24244712 http://dx.doi.org/10.1371/journal.pone.0080730 |
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