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UDP-Glucuronosyltransferase 1A Compromises Intracellular Accumulation and Anti-Cancer Effect of Tanshinone IIA in Human Colon Cancer Cells

BACKGROUND AND PURPOSE: NAD(P)H: quinone oxidoreductase 1 (NQO1) mediated quinone reduction and subsequent UDP-glucuronosyltransferases (UGTs) catalyzed glucuronidation is the dominant metabolic pathway of tanshinone IIA (TSA), a promising anti-cancer agent. UGTs are positively expressed in various...

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Detalles Bibliográficos
Autores principales:	Liu, Miao, Wang, Qiong, Liu, Fang, Cheng, Xuefang, Wu, Xiaolan, Wang, Hong, Wu, Mengqiu, Ma, Ying, Wang, Guangji, Hao, Haiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828323/ https://www.ncbi.nlm.nih.gov/pubmed/24244442 http://dx.doi.org/10.1371/journal.pone.0079172

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