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Conditional Expression of TGF-β1 in Skeletal Muscles Causes Endomysial Fibrosis and Myofibers Atrophy

To study the effects of transforming growth factor beta 1 (TGF-β1) on fibrosis and failure of regeneration of skeletal muscles, we generated a tet-repressible muscle-specific TGF-β1 transgenic mouse in which expression of TGF-β1 is controlled by oral doxycycline. The mice developed muscle weakness a...

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Detalles Bibliográficos
Autores principales:	Narola, Jigna, Pandey, Sachchida Nand, Glick, Adam, Chen, Yi-Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828351/ https://www.ncbi.nlm.nih.gov/pubmed/24244485 http://dx.doi.org/10.1371/journal.pone.0079356

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