Cargando…

Differential Regulation of Mitochondrial Pyruvate Carrier Genes Modulates Respiratory Capacity and Stress Tolerance in Yeast

Mpc proteins are highly conserved from yeast to humans and are necessary for the uptake of pyruvate at the inner mitochondrial membrane, which is used for leucine and valine biosynthesis and as a fuel for respiration. Our analysis of the yeast MPC gene family suggests that amino acid biosynthesis, r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Timón-Gómez, Alba, Proft, Markus, Pascual-Ahuir, Amparo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828368/ https://www.ncbi.nlm.nih.gov/pubmed/24244496 http://dx.doi.org/10.1371/journal.pone.0079405

Ejemplares similares

Regulation of the Stress-Activated Degradation of Mitochondrial Respiratory Complexes in Yeast
por: Timón-Gómez, Alba, et al.
Publicado: (2018)

Stress-Activated Degradation of Sphingolipids Regulates Mitochondrial Function and Cell Death in Yeast
por: Manzanares-Estreder, Sara, et al.
Publicado: (2017)

Toxicity Mechanisms of the Food Contaminant Citrinin: Application of a Quantitative Yeast Model
por: Pascual-Ahuir, Amparo, et al.
Publicado: (2014)

Different Toxicity Mechanisms for Citrinin and Ochratoxin A Revealed by Transcriptomic Analysis in Yeast
por: Vanacloig-Pedros, Elena, et al.
Publicado: (2016)

Severe acute respiratory syndrome coronavirus-2 accessory proteins ORF3a and ORF7a modulate autophagic flux and Ca(2+) homeostasis in yeast
por: Garrido-Huarte, José Luis, et al.
Publicado: (2023)

Experimental Investigations on the Structure of Yeast Mitochondrial Pyruvate Carriers
por: Li, Ling, et al.
Publicado: (2022)

Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease
por: Pascual-Ahuir, Amparo, et al.
Publicado: (2017)

Capturing and Understanding the Dynamics and Heterogeneity of Gene Expression in the Living Cell
por: Pascual-Ahuir, Amparo, et al.
Publicado: (2020)

Fungal Drug Response and Antimicrobial Resistance
por: Osset-Trénor, Paloma, et al.
Publicado: (2023)

Genomic Instability and Epigenetic Changes during Aging
por: López-Gil, Lucía, et al.
Publicado: (2023)

NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate Carrier Complexes
por: Wang, Zhen, et al.
Publicado: (2023)

The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier
por: Zangari, Joséphine, et al.
Publicado: (2020)

The yeast mitochondrial pyruvate carrier is a hetero‐dimer in its functional state
por: Tavoulari, Sotiria, et al.
Publicado: (2019)

Targeting the Mitochondrial Pyruvate Carrier for Neuroprotection
por: Tang, Bor Luen
Publicado: (2019)

The long and winding road to the mitochondrial pyruvate carrier
por: Schell, John C, et al.
Publicado: (2013)

Berberine Reduces Pyruvate-driven Hepatic Glucose Production by Limiting Mitochondrial Import of Pyruvate through Mitochondrial Pyruvate Carrier 1
por: Li, Aiyun, et al.
Publicado: (2018)

The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
por: Wenes, Mathias, et al.
Publicado: (2022)

The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity
por: Rauckhorst, Adam J., et al.
Publicado: (2017)

Function of mitochondrial pyruvate carriers in hepatocellular carcinoma patients
por: Ma, Xiangming, et al.
Publicado: (2018)

Heart failure—emerging roles for the mitochondrial pyruvate carrier
por: Fernandez-Caggiano, Mariana, et al.
Publicado: (2021)

Mitochondrial Pyruvate Carriers are Required for Myocardial Stress Adaptation
por: Zhang, Yuan, et al.
Publicado: (2020)

Mitochondrial pyruvate carrier: a metabolic-epigenetic checkpoint orchestrating T cell differentiation
por: Chen, Yu, et al.
Publicado: (2022)

Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase
por: Vendrell, Alexandre, et al.
Publicado: (2011)

Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter
por: Nagampalli, Raghavendra Sashi Krishna, et al.
Publicado: (2018)

Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy
por: Zhu, Huanhuan, et al.
Publicado: (2020)

Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy
por: Fernandez-Caggiano, Mariana, et al.
Publicado: (2020)

Mitochondrial Pyruvate Carrier Function in Health and Disease across the Lifespan
por: Buchanan, Jane L., et al.
Publicado: (2020)

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis
por: Panic, Vanja, et al.
Publicado: (2020)

Insights on the Quest for the Structure–Function Relationship of the Mitochondrial Pyruvate Carrier
por: Quesñay, José Edwin Neciosup, et al.
Publicado: (2020)

The Importance of Mitochondrial Pyruvate Carrier in Cancer Cell Metabolism and Tumorigenesis
por: Ruiz-Iglesias, Ainhoa, et al.
Publicado: (2021)

Protocol for the Analysis of Yeast and Human Mitochondrial Respiratory Chain Complexes and Supercomplexes by Blue Native Electrophoresis
por: Timón-Gómez, Alba, et al.
Publicado: (2020)

A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC
por: Arce-Molina, Robinson, et al.
Publicado: (2020)

Mitochondrial Pyruvate Carrier Subunits Are Essential for Pyruvate-Driven Respiration, Infectivity, and Intracellular Replication of Trypanosoma cruzi
por: Negreiros, Raquel S., et al.
Publicado: (2021)

An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion
por: McCommis, Kyle S., et al.
Publicado: (2016)

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death
por: Divakaruni, Ajit S., et al.
Publicado: (2017)

Metabolic Characterization and Consequences of Mitochondrial Pyruvate Carrier Deficiency in Drosophila melanogaster
por: Simard, Chloé, et al.
Publicado: (2020)

DDRE-18. THE MITOCHONDRIAL PYRUVATE CARRIER—A METABOLIC TARGET OF MALIGNANT GLIOMA
por: Tiburcio, Patricia, et al.
Publicado: (2021)

Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer
por: Tavoulari, Sotiria, et al.
Publicado: (2022)

Ketogenic Diet Treatment of Defects in the Mitochondrial Malate Aspartate Shuttle and Pyruvate Carrier
por: Bölsterli, Bigna K., et al.
Publicado: (2022)

Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19
por: Zhu, Bibo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fgvj716jpbstp9454up9ohpmld