Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection

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Germinal center (GC) B cells cycle between the dark zone (DZ) and light zone (LZ) during antibody affinity maturation. Whether this movement is necessary for GC function has not been tested. Here we show that CXCR4-deficient GC B cells, which are restricted to the LZ, are gradually outcompeted by WT...

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Detalles Bibliográficos
Autores principales: Bannard, Oliver, Horton, Robert M., Allen, Christopher D.C., An, Jinping, Nagasawa, Takashi, Cyster, Jason G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828484/
https://www.ncbi.nlm.nih.gov/pubmed/24184055
http://dx.doi.org/10.1016/j.immuni.2013.08.038

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