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Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection
Germinal center (GC) B cells cycle between the dark zone (DZ) and light zone (LZ) during antibody affinity maturation. Whether this movement is necessary for GC function has not been tested. Here we show that CXCR4-deficient GC B cells, which are restricted to the LZ, are gradually outcompeted by WT...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828484/ https://www.ncbi.nlm.nih.gov/pubmed/24184055 http://dx.doi.org/10.1016/j.immuni.2013.08.038 |
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Enlace del recurso
por Bannard, Oliver, Horton, Robert M., Allen, Christopher D.C., An, Jinping, Nagasawa, Takashi, Cyster, Jason G.
Publicado 2013
Enlace del recurso
Publicado 2013
Enlace del recurso
Online
Artículo
Texto