Models of Somatic Hypermutation Targeting and Substitution Based on Synonymous Mutations from High-Throughput Immunoglobulin Sequencing Data

Analyses of somatic hypermutation (SHM) patterns in B cell immunoglobulin (Ig) sequences contribute to our basic understanding of adaptive immunity, and have broad applications not only for understanding the immune response to pathogens, but also to determining the role of SHM in autoimmunity and B...

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Detalles Bibliográficos
Autores principales: Yaari, Gur, Vander Heiden, Jason A., Uduman, Mohamed, Gadala-Maria, Daniel, Gupta, Namita, Stern, Joel N. H., O’Connor, Kevin C., Hafler, David A., Laserson, Uri, Vigneault, Francois, Kleinstein, Steven H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828525/
https://www.ncbi.nlm.nih.gov/pubmed/24298272
http://dx.doi.org/10.3389/fimmu.2013.00358

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