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Cell therapy of periodontium: from animal to human?

Periodontitis is a chronic inflammatory disease affecting the soft and hard tissues supporting the teeth, which often leads to tooth loss. Its significant impact on the patient's general health and quality of life point to a need for more effective management of this condition. Existing treatme...

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Detalles Bibliográficos
Autores principales: Trofin, Elena A., Monsarrat, Paul, Kémoun, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828527/
https://www.ncbi.nlm.nih.gov/pubmed/24298258
http://dx.doi.org/10.3389/fphys.2013.00325
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author Trofin, Elena A.
Monsarrat, Paul
Kémoun, Philippe
author_facet Trofin, Elena A.
Monsarrat, Paul
Kémoun, Philippe
author_sort Trofin, Elena A.
collection PubMed
description Periodontitis is a chronic inflammatory disease affecting the soft and hard tissues supporting the teeth, which often leads to tooth loss. Its significant impact on the patient's general health and quality of life point to a need for more effective management of this condition. Existing treatments include scaling/root planning and surgical approaches but their overall effects are relatively modest and restricted in application. The goal of regenerative therapy of periodontal defects is to enhance endogenous progenitors and thus promote optimal wound healing. Considering that the host or tissue might be defective in the periodontitis context, it has been proposed that grafting exogenous stem cells would produce new tissues and create a suitable microenvironment for tissue regeneration. Thus, cell therapy of periodontium has been assessed in many animal models and promising results have been reported. However, the methodological diversity of these studies makes the conversion to clinical practice difficult. The aim of this review is to highlight the primary requirements to be satisfied before the leap to clinical trials can be made. We therefore review cell therapy applications for periodontal regeneration in animal models and the concerns to be addressed before undertaking human experiments.
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spelling pubmed-38285272013-12-02 Cell therapy of periodontium: from animal to human? Trofin, Elena A. Monsarrat, Paul Kémoun, Philippe Front Physiol Physiology Periodontitis is a chronic inflammatory disease affecting the soft and hard tissues supporting the teeth, which often leads to tooth loss. Its significant impact on the patient's general health and quality of life point to a need for more effective management of this condition. Existing treatments include scaling/root planning and surgical approaches but their overall effects are relatively modest and restricted in application. The goal of regenerative therapy of periodontal defects is to enhance endogenous progenitors and thus promote optimal wound healing. Considering that the host or tissue might be defective in the periodontitis context, it has been proposed that grafting exogenous stem cells would produce new tissues and create a suitable microenvironment for tissue regeneration. Thus, cell therapy of periodontium has been assessed in many animal models and promising results have been reported. However, the methodological diversity of these studies makes the conversion to clinical practice difficult. The aim of this review is to highlight the primary requirements to be satisfied before the leap to clinical trials can be made. We therefore review cell therapy applications for periodontal regeneration in animal models and the concerns to be addressed before undertaking human experiments. Frontiers Media S.A. 2013-11-15 /pmc/articles/PMC3828527/ /pubmed/24298258 http://dx.doi.org/10.3389/fphys.2013.00325 Text en Copyright © 2013 Trofin, Monsarrat and Kémoun. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Trofin, Elena A.
Monsarrat, Paul
Kémoun, Philippe
Cell therapy of periodontium: from animal to human?
title Cell therapy of periodontium: from animal to human?
title_full Cell therapy of periodontium: from animal to human?
title_fullStr Cell therapy of periodontium: from animal to human?
title_full_unstemmed Cell therapy of periodontium: from animal to human?
title_short Cell therapy of periodontium: from animal to human?
title_sort cell therapy of periodontium: from animal to human?
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828527/
https://www.ncbi.nlm.nih.gov/pubmed/24298258
http://dx.doi.org/10.3389/fphys.2013.00325
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