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Toward a Molecular Classification of Colorectal Cancer: The Role of BRAF
Different genetic aberrations of BRAF have been reported in various malignancies. BRAF is member of the RAS/RAF/MEK/ERK pathway and constitutive activity of this pathway can lead to increased cellular growth, invasion, and metastasis. The most common activating BRAF mutation in colorectal cancer is...
Autores principales: | Thiel, Alexandra, Ristimäki, Ari |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828559/ https://www.ncbi.nlm.nih.gov/pubmed/24298448 http://dx.doi.org/10.3389/fonc.2013.00281 |
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