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mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions

Pancreatic cancer is characterized by near-universal mutations in KRAS. The mammalian target of rapamycin (mTOR), which functions downstream of RAS, has divergent effects on stem cells. In the present study, we investigated the significance of the mTOR pathway in maintaining the properties of pancre...

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Detalles Bibliográficos
Autores principales:	Matsubara, Shyuichiro, Ding, Qiang, Miyazaki, Yumi, Kuwahata, Taisaku, Tsukasa, Koichiro, Takao, Sonshin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828572/ https://www.ncbi.nlm.nih.gov/pubmed/24231729 http://dx.doi.org/10.1038/srep03230

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