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mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions
Pancreatic cancer is characterized by near-universal mutations in KRAS. The mammalian target of rapamycin (mTOR), which functions downstream of RAS, has divergent effects on stem cells. In the present study, we investigated the significance of the mTOR pathway in maintaining the properties of pancre...
Autores principales: | Matsubara, Shyuichiro, Ding, Qiang, Miyazaki, Yumi, Kuwahata, Taisaku, Tsukasa, Koichiro, Takao, Sonshin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828572/ https://www.ncbi.nlm.nih.gov/pubmed/24231729 http://dx.doi.org/10.1038/srep03230 |
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