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Hydrogen Peroxide–Mediated SERCA Cysteine 674 Oxidation Contributes to Impaired Cardiac Myocyte Relaxation in Senescent Mouse Heart

BACKGROUND: A hallmark of aging of the cardiac myocyte is impaired sarcoplasmic reticulum (SR) calcium uptake and relaxation due to decreased SR calcium ATPase (SERCA) activity. We tested the hypothesis that H(2)O(2)‐mediated oxidation of SERCA contributes to impaired myocyte relaxation in aging. ME...

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Detalles Bibliográficos
Autores principales:	Qin, Fuzhong, Siwik, Deborah A., Lancel, Steve, Zhang, Jingmei, Kuster, Gabriela M., Luptak, Ivan, Wang, Lei, Tong, Xiaoyong, Kang, Y. James, Cohen, Richard A., Colucci, Wilson S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828801/ https://www.ncbi.nlm.nih.gov/pubmed/23963753 http://dx.doi.org/10.1161/JAHA.113.000184

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