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Myocardial Tissue Remodeling in Adolescent Obesity
BACKGROUND: Childhood obesity is a significant risk factor for cardiovascular disease in adulthood. Although ventricular remodeling has been reported in obese youth, early tissue‐level markers within the myocardium that precede organ‐level alterations have not been described. METHODS AND RESULTS: We...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828806/ https://www.ncbi.nlm.nih.gov/pubmed/23963758 http://dx.doi.org/10.1161/JAHA.113.000279 |
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author | Shah, Ravi V. Abbasi, Siddique A. Neilan, Tomas G. Hulten, Edward Coelho‐Filho, Otavio Hoppin, Alison Levitsky, Lynne de Ferranti, Sarah Rhodes, Erinn T. Traum, Avram Goodman, Elizabeth Feng, Henry Heydari, Bobak Harris, William S. Hoefner, Daniel M. McConnell, Joseph P. Seethamraju, Ravi Rickers, Carsten Kwong, Raymond Y. Jerosch‐Herold, Michael |
author_facet | Shah, Ravi V. Abbasi, Siddique A. Neilan, Tomas G. Hulten, Edward Coelho‐Filho, Otavio Hoppin, Alison Levitsky, Lynne de Ferranti, Sarah Rhodes, Erinn T. Traum, Avram Goodman, Elizabeth Feng, Henry Heydari, Bobak Harris, William S. Hoefner, Daniel M. McConnell, Joseph P. Seethamraju, Ravi Rickers, Carsten Kwong, Raymond Y. Jerosch‐Herold, Michael |
author_sort | Shah, Ravi V. |
collection | PubMed |
description | BACKGROUND: Childhood obesity is a significant risk factor for cardiovascular disease in adulthood. Although ventricular remodeling has been reported in obese youth, early tissue‐level markers within the myocardium that precede organ‐level alterations have not been described. METHODS AND RESULTS: We studied 21 obese adolescents (mean age, 17.7±2.6 years; mean body mass index [BMI], 41.9±9.5 kg/m(2), including 11 patients with type 2 diabetes [T2D]) and 12 healthy volunteers (age, 15.1±4.5 years; BMI, 20.1±3.5 kg/m(2)) using biomarkers of cardiometabolic risk and cardiac magnetic resonance imaging (CMR) to phenotype cardiac structure, function, and interstitial matrix remodeling by standard techniques. Although left ventricular ejection fraction and left atrial volumes were similar in healthy volunteers and obese patients (and within normal body size‐adjusted limits), interstitial matrix expansion by CMR extracellular volume fraction (ECV) was significantly different between healthy volunteers (median, 0.264; interquartile range [IQR], 0.253 to 0.271), obese adolescents without T2D (median, 0.328; IQR, 0.278 to 0.345), and obese adolescents with T2D (median, 0.376; IQR, 0.336 to 0.407; P=0.0001). ECV was associated with BMI for the entire population (r=0.58, P<0.001) and with high‐sensitivity C‐reactive protein (r=0.47, P<0.05), serum triglycerides (r=0.51, P<0.05), and hemoglobin A1c (r=0.76, P<0.0001) in the obese stratum. CONCLUSIONS: Obese adolescents (particularly those with T2D) have subclinical alterations in myocardial tissue architecture associated with inflammation and insulin resistance. These alterations precede significant left ventricular hypertrophy or decreased cardiac function. |
format | Online Article Text |
id | pubmed-3828806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38288062013-11-19 Myocardial Tissue Remodeling in Adolescent Obesity Shah, Ravi V. Abbasi, Siddique A. Neilan, Tomas G. Hulten, Edward Coelho‐Filho, Otavio Hoppin, Alison Levitsky, Lynne de Ferranti, Sarah Rhodes, Erinn T. Traum, Avram Goodman, Elizabeth Feng, Henry Heydari, Bobak Harris, William S. Hoefner, Daniel M. McConnell, Joseph P. Seethamraju, Ravi Rickers, Carsten Kwong, Raymond Y. Jerosch‐Herold, Michael J Am Heart Assoc Original Research BACKGROUND: Childhood obesity is a significant risk factor for cardiovascular disease in adulthood. Although ventricular remodeling has been reported in obese youth, early tissue‐level markers within the myocardium that precede organ‐level alterations have not been described. METHODS AND RESULTS: We studied 21 obese adolescents (mean age, 17.7±2.6 years; mean body mass index [BMI], 41.9±9.5 kg/m(2), including 11 patients with type 2 diabetes [T2D]) and 12 healthy volunteers (age, 15.1±4.5 years; BMI, 20.1±3.5 kg/m(2)) using biomarkers of cardiometabolic risk and cardiac magnetic resonance imaging (CMR) to phenotype cardiac structure, function, and interstitial matrix remodeling by standard techniques. Although left ventricular ejection fraction and left atrial volumes were similar in healthy volunteers and obese patients (and within normal body size‐adjusted limits), interstitial matrix expansion by CMR extracellular volume fraction (ECV) was significantly different between healthy volunteers (median, 0.264; interquartile range [IQR], 0.253 to 0.271), obese adolescents without T2D (median, 0.328; IQR, 0.278 to 0.345), and obese adolescents with T2D (median, 0.376; IQR, 0.336 to 0.407; P=0.0001). ECV was associated with BMI for the entire population (r=0.58, P<0.001) and with high‐sensitivity C‐reactive protein (r=0.47, P<0.05), serum triglycerides (r=0.51, P<0.05), and hemoglobin A1c (r=0.76, P<0.0001) in the obese stratum. CONCLUSIONS: Obese adolescents (particularly those with T2D) have subclinical alterations in myocardial tissue architecture associated with inflammation and insulin resistance. These alterations precede significant left ventricular hypertrophy or decreased cardiac function. Blackwell Publishing Ltd 2013-08-23 /pmc/articles/PMC3828806/ /pubmed/23963758 http://dx.doi.org/10.1161/JAHA.113.000279 Text en © 2013 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley-Blackwell. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article under the terms of the Creative Commons Attribution Noncommercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research Shah, Ravi V. Abbasi, Siddique A. Neilan, Tomas G. Hulten, Edward Coelho‐Filho, Otavio Hoppin, Alison Levitsky, Lynne de Ferranti, Sarah Rhodes, Erinn T. Traum, Avram Goodman, Elizabeth Feng, Henry Heydari, Bobak Harris, William S. Hoefner, Daniel M. McConnell, Joseph P. Seethamraju, Ravi Rickers, Carsten Kwong, Raymond Y. Jerosch‐Herold, Michael Myocardial Tissue Remodeling in Adolescent Obesity |
title | Myocardial Tissue Remodeling in Adolescent Obesity |
title_full | Myocardial Tissue Remodeling in Adolescent Obesity |
title_fullStr | Myocardial Tissue Remodeling in Adolescent Obesity |
title_full_unstemmed | Myocardial Tissue Remodeling in Adolescent Obesity |
title_short | Myocardial Tissue Remodeling in Adolescent Obesity |
title_sort | myocardial tissue remodeling in adolescent obesity |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828806/ https://www.ncbi.nlm.nih.gov/pubmed/23963758 http://dx.doi.org/10.1161/JAHA.113.000279 |
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