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Myocardial Tissue Remodeling in Adolescent Obesity

BACKGROUND: Childhood obesity is a significant risk factor for cardiovascular disease in adulthood. Although ventricular remodeling has been reported in obese youth, early tissue‐level markers within the myocardium that precede organ‐level alterations have not been described. METHODS AND RESULTS: We...

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Autores principales: Shah, Ravi V., Abbasi, Siddique A., Neilan, Tomas G., Hulten, Edward, Coelho‐Filho, Otavio, Hoppin, Alison, Levitsky, Lynne, de Ferranti, Sarah, Rhodes, Erinn T., Traum, Avram, Goodman, Elizabeth, Feng, Henry, Heydari, Bobak, Harris, William S., Hoefner, Daniel M., McConnell, Joseph P., Seethamraju, Ravi, Rickers, Carsten, Kwong, Raymond Y., Jerosch‐Herold, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828806/
https://www.ncbi.nlm.nih.gov/pubmed/23963758
http://dx.doi.org/10.1161/JAHA.113.000279
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author Shah, Ravi V.
Abbasi, Siddique A.
Neilan, Tomas G.
Hulten, Edward
Coelho‐Filho, Otavio
Hoppin, Alison
Levitsky, Lynne
de Ferranti, Sarah
Rhodes, Erinn T.
Traum, Avram
Goodman, Elizabeth
Feng, Henry
Heydari, Bobak
Harris, William S.
Hoefner, Daniel M.
McConnell, Joseph P.
Seethamraju, Ravi
Rickers, Carsten
Kwong, Raymond Y.
Jerosch‐Herold, Michael
author_facet Shah, Ravi V.
Abbasi, Siddique A.
Neilan, Tomas G.
Hulten, Edward
Coelho‐Filho, Otavio
Hoppin, Alison
Levitsky, Lynne
de Ferranti, Sarah
Rhodes, Erinn T.
Traum, Avram
Goodman, Elizabeth
Feng, Henry
Heydari, Bobak
Harris, William S.
Hoefner, Daniel M.
McConnell, Joseph P.
Seethamraju, Ravi
Rickers, Carsten
Kwong, Raymond Y.
Jerosch‐Herold, Michael
author_sort Shah, Ravi V.
collection PubMed
description BACKGROUND: Childhood obesity is a significant risk factor for cardiovascular disease in adulthood. Although ventricular remodeling has been reported in obese youth, early tissue‐level markers within the myocardium that precede organ‐level alterations have not been described. METHODS AND RESULTS: We studied 21 obese adolescents (mean age, 17.7±2.6 years; mean body mass index [BMI], 41.9±9.5 kg/m(2), including 11 patients with type 2 diabetes [T2D]) and 12 healthy volunteers (age, 15.1±4.5 years; BMI, 20.1±3.5 kg/m(2)) using biomarkers of cardiometabolic risk and cardiac magnetic resonance imaging (CMR) to phenotype cardiac structure, function, and interstitial matrix remodeling by standard techniques. Although left ventricular ejection fraction and left atrial volumes were similar in healthy volunteers and obese patients (and within normal body size‐adjusted limits), interstitial matrix expansion by CMR extracellular volume fraction (ECV) was significantly different between healthy volunteers (median, 0.264; interquartile range [IQR], 0.253 to 0.271), obese adolescents without T2D (median, 0.328; IQR, 0.278 to 0.345), and obese adolescents with T2D (median, 0.376; IQR, 0.336 to 0.407; P=0.0001). ECV was associated with BMI for the entire population (r=0.58, P<0.001) and with high‐sensitivity C‐reactive protein (r=0.47, P<0.05), serum triglycerides (r=0.51, P<0.05), and hemoglobin A1c (r=0.76, P<0.0001) in the obese stratum. CONCLUSIONS: Obese adolescents (particularly those with T2D) have subclinical alterations in myocardial tissue architecture associated with inflammation and insulin resistance. These alterations precede significant left ventricular hypertrophy or decreased cardiac function.
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spelling pubmed-38288062013-11-19 Myocardial Tissue Remodeling in Adolescent Obesity Shah, Ravi V. Abbasi, Siddique A. Neilan, Tomas G. Hulten, Edward Coelho‐Filho, Otavio Hoppin, Alison Levitsky, Lynne de Ferranti, Sarah Rhodes, Erinn T. Traum, Avram Goodman, Elizabeth Feng, Henry Heydari, Bobak Harris, William S. Hoefner, Daniel M. McConnell, Joseph P. Seethamraju, Ravi Rickers, Carsten Kwong, Raymond Y. Jerosch‐Herold, Michael J Am Heart Assoc Original Research BACKGROUND: Childhood obesity is a significant risk factor for cardiovascular disease in adulthood. Although ventricular remodeling has been reported in obese youth, early tissue‐level markers within the myocardium that precede organ‐level alterations have not been described. METHODS AND RESULTS: We studied 21 obese adolescents (mean age, 17.7±2.6 years; mean body mass index [BMI], 41.9±9.5 kg/m(2), including 11 patients with type 2 diabetes [T2D]) and 12 healthy volunteers (age, 15.1±4.5 years; BMI, 20.1±3.5 kg/m(2)) using biomarkers of cardiometabolic risk and cardiac magnetic resonance imaging (CMR) to phenotype cardiac structure, function, and interstitial matrix remodeling by standard techniques. Although left ventricular ejection fraction and left atrial volumes were similar in healthy volunteers and obese patients (and within normal body size‐adjusted limits), interstitial matrix expansion by CMR extracellular volume fraction (ECV) was significantly different between healthy volunteers (median, 0.264; interquartile range [IQR], 0.253 to 0.271), obese adolescents without T2D (median, 0.328; IQR, 0.278 to 0.345), and obese adolescents with T2D (median, 0.376; IQR, 0.336 to 0.407; P=0.0001). ECV was associated with BMI for the entire population (r=0.58, P<0.001) and with high‐sensitivity C‐reactive protein (r=0.47, P<0.05), serum triglycerides (r=0.51, P<0.05), and hemoglobin A1c (r=0.76, P<0.0001) in the obese stratum. CONCLUSIONS: Obese adolescents (particularly those with T2D) have subclinical alterations in myocardial tissue architecture associated with inflammation and insulin resistance. These alterations precede significant left ventricular hypertrophy or decreased cardiac function. Blackwell Publishing Ltd 2013-08-23 /pmc/articles/PMC3828806/ /pubmed/23963758 http://dx.doi.org/10.1161/JAHA.113.000279 Text en © 2013 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley-Blackwell. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article under the terms of the Creative Commons Attribution Noncommercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Research
Shah, Ravi V.
Abbasi, Siddique A.
Neilan, Tomas G.
Hulten, Edward
Coelho‐Filho, Otavio
Hoppin, Alison
Levitsky, Lynne
de Ferranti, Sarah
Rhodes, Erinn T.
Traum, Avram
Goodman, Elizabeth
Feng, Henry
Heydari, Bobak
Harris, William S.
Hoefner, Daniel M.
McConnell, Joseph P.
Seethamraju, Ravi
Rickers, Carsten
Kwong, Raymond Y.
Jerosch‐Herold, Michael
Myocardial Tissue Remodeling in Adolescent Obesity
title Myocardial Tissue Remodeling in Adolescent Obesity
title_full Myocardial Tissue Remodeling in Adolescent Obesity
title_fullStr Myocardial Tissue Remodeling in Adolescent Obesity
title_full_unstemmed Myocardial Tissue Remodeling in Adolescent Obesity
title_short Myocardial Tissue Remodeling in Adolescent Obesity
title_sort myocardial tissue remodeling in adolescent obesity
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828806/
https://www.ncbi.nlm.nih.gov/pubmed/23963758
http://dx.doi.org/10.1161/JAHA.113.000279
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