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The role of caspase-2 in stress-induced apoptosis
Caspase-2 is the most evolutionarily conserved of all the caspases, yet it has a poorly defined role in apoptotic pathways. This is mainly due to a dearth of techniques to determine the activation status of caspase-2 and the lack of an abnormal phenotype in caspase-2 deficient mice. Nevertheless, em...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Blackwell Publishing Ltd
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828840/ https://www.ncbi.nlm.nih.gov/pubmed/20158568 http://dx.doi.org/10.1111/j.1582-4934.2010.01037.x |
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author | Bouchier-Hayes, Lisa |
author_facet | Bouchier-Hayes, Lisa |
author_sort | Bouchier-Hayes, Lisa |
collection | PubMed |
description | Caspase-2 is the most evolutionarily conserved of all the caspases, yet it has a poorly defined role in apoptotic pathways. This is mainly due to a dearth of techniques to determine the activation status of caspase-2 and the lack of an abnormal phenotype in caspase-2 deficient mice. Nevertheless, emerging evidence suggests that caspase-2 may have important functions in a number of stress-induced cell death pathways, in cell cycle maintenance and regulation of tumour progression. This review discusses recent advances that have been made to help elucidate the true role of this elusive caspase and the potential contribution of caspase-2 to the pathology of human diseases including cancer. |
format | Online Article Text |
id | pubmed-3828840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38288402015-04-20 The role of caspase-2 in stress-induced apoptosis Bouchier-Hayes, Lisa J Cell Mol Med Reviews Caspase-2 is the most evolutionarily conserved of all the caspases, yet it has a poorly defined role in apoptotic pathways. This is mainly due to a dearth of techniques to determine the activation status of caspase-2 and the lack of an abnormal phenotype in caspase-2 deficient mice. Nevertheless, emerging evidence suggests that caspase-2 may have important functions in a number of stress-induced cell death pathways, in cell cycle maintenance and regulation of tumour progression. This review discusses recent advances that have been made to help elucidate the true role of this elusive caspase and the potential contribution of caspase-2 to the pathology of human diseases including cancer. Blackwell Publishing Ltd 2010-06 2010-02-16 /pmc/articles/PMC3828840/ /pubmed/20158568 http://dx.doi.org/10.1111/j.1582-4934.2010.01037.x Text en © 2010 The Author Journal compilation © 2010 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd |
spellingShingle | Reviews Bouchier-Hayes, Lisa The role of caspase-2 in stress-induced apoptosis |
title | The role of caspase-2 in stress-induced apoptosis |
title_full | The role of caspase-2 in stress-induced apoptosis |
title_fullStr | The role of caspase-2 in stress-induced apoptosis |
title_full_unstemmed | The role of caspase-2 in stress-induced apoptosis |
title_short | The role of caspase-2 in stress-induced apoptosis |
title_sort | role of caspase-2 in stress-induced apoptosis |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828840/ https://www.ncbi.nlm.nih.gov/pubmed/20158568 http://dx.doi.org/10.1111/j.1582-4934.2010.01037.x |
work_keys_str_mv | AT bouchierhayeslisa theroleofcaspase2instressinducedapoptosis AT bouchierhayeslisa roleofcaspase2instressinducedapoptosis |