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The role of caspase-2 in stress-induced apoptosis

Caspase-2 is the most evolutionarily conserved of all the caspases, yet it has a poorly defined role in apoptotic pathways. This is mainly due to a dearth of techniques to determine the activation status of caspase-2 and the lack of an abnormal phenotype in caspase-2 deficient mice. Nevertheless, em...

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Detalles Bibliográficos
Autor principal: Bouchier-Hayes, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828840/
https://www.ncbi.nlm.nih.gov/pubmed/20158568
http://dx.doi.org/10.1111/j.1582-4934.2010.01037.x
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author Bouchier-Hayes, Lisa
author_facet Bouchier-Hayes, Lisa
author_sort Bouchier-Hayes, Lisa
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description Caspase-2 is the most evolutionarily conserved of all the caspases, yet it has a poorly defined role in apoptotic pathways. This is mainly due to a dearth of techniques to determine the activation status of caspase-2 and the lack of an abnormal phenotype in caspase-2 deficient mice. Nevertheless, emerging evidence suggests that caspase-2 may have important functions in a number of stress-induced cell death pathways, in cell cycle maintenance and regulation of tumour progression. This review discusses recent advances that have been made to help elucidate the true role of this elusive caspase and the potential contribution of caspase-2 to the pathology of human diseases including cancer.
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spelling pubmed-38288402015-04-20 The role of caspase-2 in stress-induced apoptosis Bouchier-Hayes, Lisa J Cell Mol Med Reviews Caspase-2 is the most evolutionarily conserved of all the caspases, yet it has a poorly defined role in apoptotic pathways. This is mainly due to a dearth of techniques to determine the activation status of caspase-2 and the lack of an abnormal phenotype in caspase-2 deficient mice. Nevertheless, emerging evidence suggests that caspase-2 may have important functions in a number of stress-induced cell death pathways, in cell cycle maintenance and regulation of tumour progression. This review discusses recent advances that have been made to help elucidate the true role of this elusive caspase and the potential contribution of caspase-2 to the pathology of human diseases including cancer. Blackwell Publishing Ltd 2010-06 2010-02-16 /pmc/articles/PMC3828840/ /pubmed/20158568 http://dx.doi.org/10.1111/j.1582-4934.2010.01037.x Text en © 2010 The Author Journal compilation © 2010 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
spellingShingle Reviews
Bouchier-Hayes, Lisa
The role of caspase-2 in stress-induced apoptosis
title The role of caspase-2 in stress-induced apoptosis
title_full The role of caspase-2 in stress-induced apoptosis
title_fullStr The role of caspase-2 in stress-induced apoptosis
title_full_unstemmed The role of caspase-2 in stress-induced apoptosis
title_short The role of caspase-2 in stress-induced apoptosis
title_sort role of caspase-2 in stress-induced apoptosis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828840/
https://www.ncbi.nlm.nih.gov/pubmed/20158568
http://dx.doi.org/10.1111/j.1582-4934.2010.01037.x
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